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Science and Technology Daily, Kunming, January 19 (Reporter Hanbin Zhao) The pathogenesis of Alzheimer's disease is very complicated, and there is a lack of clinically effective cures or drugs. The reporter learned from the Kunming Institute of Botany, Chinese Academy of Sciences on the 19th that our researchers have recently discovered for the first time that limonoid compounds may be used as lead compounds for the treatment of Alzheimer's disease, which provides new ideas for the research and development of new drugs.
Alzheimer's disease, also known as Alzheimer's disease, is one of the most common neurodegenerative diseases that occurs in old age. At present, my country has the world's largest group of patients with such diseases, and its care and treatment have brought a heavy burden to the family and society. In recent years, the exploration of potential targets of new drugs for Alzheimer's disease and the development of drugs that act on potential new drug targets have been the direction of exploration by major pharmaceutical companies and research institutes. In my country, strengthening preventive interventions such as senile disability and Alzheimer's has been listed as a major task for comprehensively promoting the construction of a healthy China during the "14th Five-Year Plan" period.
Previously, the research group of Academician Hao Xiaojiang of the Phytochemical Biology Team of the Kunming Institute of Botany, Chinese Academy of Sciences has long been committed to the discovery of plant-derived active substances against Alzheimer’s disease, and has achieved a series of results. For example, the collaboration with the research group of Cai Jingxia of the Kunming Institute of Zoology has entered Phase II clinical "Fincrotone"; in collaboration with Yang Chonglin's research group from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, discovered important active lead compounds such as ingenol ester that can promote lysosome production.
Recently, Hao Xiaojiang's research group cooperated with our institute's Yao Yonggang's research group and discovered novel structural limonin compounds in the plant sorrelaceae gooseberry, and its structure was finally confirmed by X-ray single crystal diffraction experiments. Western blotting technology, enzyme-linked immunosorbent assay and cell transcriptome sequencing analysis found that this compound can act through multiple targets. This innovative discovery may bring a turning point in the future development of new drugs for Alzheimer's disease. Related achievements were published in the authoritative organic chemistry journal "Organic Chemistry Communications" as a cover article, and have applied for invention patent protection.