Coronary heart disease is currently the most common type of cardiovascular disease in the world, and it is also one of the leading causes of death worldwide. Its etiology and pathogenesis are complex and have not yet been fully clarified. In recent years, with the development of high-throughput chromatography and mass spectrometry technology, as well as breakthroughs in microbial map sequencing and analysis methods, metabolomics technology and metagenomics technology have been applied to population research and animal research, revealing the intestinal tract from a new perspective. Interactions between the microbiota and host metabolism and immunity that significantly influence the risk of cardiovascular disease. However, the role of gut microbiota in the development of coronary heart disease is still unclear, and the value of gut microbiota intervention in adjuvant therapy still needs further evaluation. Understanding the mechanism by which intestinal flora and its metabolites affect the occurrence and development of coronary heart disease is expected to provide a new perspective for the development of prevention and intervention measures for coronary heart disease, which is of great significance to the prevention and treatment of coronary heart disease.
Recently, academician Ge Junbo of Zhongshan Hospital affiliated to Fudan University and researcher Zheng Yan of the School of Life Sciences of Fudan University jointly published an expert review article titled "Recent advances in the gut microbiome and microbial metabolites alterations of coronary artery disease" in Science Bulletin . The biological mechanism of midgut microbiota involvement and the latest progress of microbiota intervention strategies are summarized and prospected.
This article summarizes the structural and metabolite changes of gut microbiota in coronary heart disease, and discusses the underlying mechanism by which these changes affect the development of the disease. Compared with healthy people, the structure of intestinal flora in patients with coronary heart disease has undergone significant changes. The imbalance of flora structure is related to human lipid metabolism and immune disorders, which in turn promotes the occurrence of coronary heart disease. In addition, circulating metabolites from a variety of intestinal flora, such as trimethylamine oxide, short-chain fatty acids, and bile acids, can promote or inhibit vascular atherosclerosis by affecting the intestinal barrier, lipid transport, and secretion of inflammatory factors. phenotype and plaque stability. These biomarkers are expected to open up new ideas for the early prediction and treatment of coronary heart disease.
At the same time, this paper also puts forward the future prospect of the research on coronary heart disease and intestinal flora. First of all, due to the influence of geographical environment, the research results of flora in different regions and different populations are highly heterogeneous, and it is necessary to more accurately develop flora intervention targets based on the differences between populations; secondly, based on the characteristics of individual gut flora Precision nutrition has become one of the first-line methods for the management of chronic diseases. It is necessary to deeply explore the interaction of diet-gut flora-coronary heart disease and its underlying mechanism, so as to provide personalized nutritional guidance for the prevention and treatment of coronary heart disease. Although it cannot completely replace other prevention and treatment methods of coronary heart disease, such as the use of lipid-lowering drugs and appropriate physical activity, with the development of further research, nutritional intervention and drug treatment targeting intestinal flora are expected to become part of the prevention and treatment strategy of coronary heart disease. An important part.
Dai Yuxiang from the Cardiology Department of Zhongshan Hospital Affiliated to Fudan University is the first author of the article, Sun Zhonghan from the School of Life Sciences of Fudan University is the second author, and Academician Ge Junbo and Researcher Zheng Yan are the co-corresponding authors. This article was supported by the National Key Research and Development Program (2021YFC2500500), the National Natural Science Foundation of China (81973032), the Shanghai Shenkang Major Disease Clinical Research Project (SHDC2020CR1007A), and the Shanghai Excellent Academic Leader Program (22XD1423300).
To learn more about the research, please visit the official website of the journal to read the full text. [Click the link below or read the original text]▼
Yuxiang Dai, Zhonghan Sun, Yan Zheng, Junbo Ge. Recent advances in the gut microbiome and microbial metabolites alterations of coronary artery disease. Science Bulletin 2023. https://doi.org/10.1016/j.scib.2023.03.009.
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