Source: authors reported 21st Century Business: Zhu Lina reporting from Hong Kong
Just now, Yuan Guoyong, Chair Professor of the Department of Microbiology of the University of Hong Kong, told the Hong Kong media that the Department of Microbiology of the University of Hong Kong has successfully isolated the virus strain of the "first Hong Kong case" and developed a new coronavirus vaccine, which will be tested on animals before entering clinical trials.
Yuan Guoyong said that the vaccine is a nasal spray and has been published in international medical journals (patented). The Department of Microbiology of the University of Hong Kong has sequenced the virus' entry genes. Later, in experiments, the surface protein of the virus was used to try to invade human cells, showing its ability to prevent infection with the new coronavirus.The next step will be animal experiments, and then human clinical experiments.
At the same time, the University of Hong Kong School of Medicine estimates that in response to the peak of the epidemic, there is currently no specific medicine for the treatment of the new coronavirus, and vaccination is the most effective means of protection.
Source: Hong Kong Fax
Hong Kong University infectious disease expert Yuan Guoyong: New pneumonia virus vaccine seeds have been developed
Yuan Guoyong, Chair Professor of the Department of Microbiology, University of Hong Kong School of Medicine, stated on a radio program on January 29 that his research team has successfully isolated the virus strain of the coronavirus and has now developed the seeds for the relevant vaccine.
Yuan Guoyong pointed out that the current research team has successfully discovered the genetic sequencing of the coronavirus in samples of confirmed cases of new pneumonia in Shenzhen Hong Kong University Hospital, and put the long spike protein, the protein of the virus surface antigen, into the influenza vaccine. Researchers have discovered that coronaviruses need to rely on spike proteins to attack human cells for reproduction. He explained that if the development is successful, in the future, the flu vaccine can be sprayed into the nose to produce comprehensive antibodies against the coronavirus.
However, he said frankly that there is no timetable to predict when the vaccine will be available on the market. "It is necessary to conduct animal tests to confirm the effectiveness and safety of the vaccine, and hope that it can cooperate with vaccine companies in the Mainland to produce related vaccines and conduct clinical trials. "
At the same time, he revealed that some past measles vaccine studies have shown that after a patient is injected with an inactivated vaccine, the virus is killed by a chemical method. Although the patient develops antibodies, when the patient encounters the measles virus, the condition is worse.
"Therefore, we are not injecting the entire virus protein into the patient's body this time, but only putting the spike protein into the flu vaccine, hoping to prevent an abnormal immune response." He said.
He revealed that researchers have isolated the virus strain in the first imported confirmed case in Hong Kong, successfully planted the relevant coronavirus, and began to conduct challenge tests to test the response of the virus on different animals, and then spray the nasal vaccine Spray into the animal's nose to confirm whether it can produce a protective effect.
At the same time, he pointed out that in terms of clinical treatment, there are no antiviral drugs for new pneumonia. According to the experience of SARS in 2003, certain anti-AIDS drugs have a certain effect on SARS and Middle East Respiratory Syndrome. "We hope that in a few weeks Let me tell you whether this drug is also effective against the new coronavirus."
Yuan Guoyong is a member of the high-level expert group of the National Health Commission and is known as the authority on infectious diseases in Hong Kong. He played a vital role in the discovery of the SARS-infected pathogen, the SARS coronavirus, in 2003.
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