Source: ATYUN AI platform
CRISPR gene editing technology may very well eliminate the world's most serious diseases, so that we can simply edit the genetic code of disease. However, the one thing that fantasy into reality the problem is off target effects. Now, Microsoft hopes to use artificial intelligence to solve this problem.
CRISPR is famous because of its accuracy. Compared with earlier genetic techniques, it can be accurately aimed and changing a small part of the genetic code. It is not always as accurate as we would like, but at least some of the time, CRISPR originally intended to stay for a separate DNA modified. Depending on these changes, they may lead to new health problems inadvertently, such as cancer.
For a long time, scientists have been fine-tuning CRISPR research methods in order to reduce the occurrence of these unexpected effects. Microsoft believes that artificial intelligence could be a way to achieve this functionality. By working with computer scientists and biologists from research institutions around the United States, Microsoft has developed a new tool called Elevation, which may have the effect of predicted off-target gene CRISPR when in editing.
It works like this: if a scientist going to change a particular gene, they will enter its name to Elevation. CRISPR system consists of two parts, a cutting protein, a synthetic guide is an RNA, DNA sequence of the gene to match in their want to edit. The wizard can have different effects of different off-target, depending on their use. Elevation Wizard will show what kind least likely to lead to non-target effects of specific genes, this problem can be solved using machine learning. It also provides general feedback on the impact of deviation from the target gene of interest to target. This platform is based on Microsoft's research and publicly available data, the main data on different gene targets and guidelines for how to interact.
- The details of the study can be seen here: https://www.nature.com/natbiomedeng/https://www.nature.com/articles/s41551-017-0178-6
What problems exist in the end-target effects on CRISPR and how to fix these problems, there is a lot of controversy. However, Microsoft's new tool will no doubt be very popular. In addition, in the past year, Microsoft has been working to use artificial intelligence to solve the health care problem.
This switched ATYUN artificial intelligence media platforms, the original link: Microsoft AI makes use of CRISPR become more precise, or the technology to achieve a breakthrough in gene editing
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