Read the article: What is the health care effect of nmn, and the biggest effect of nmn! β-nicotinamide mononucleotide (NMN), its molecular formula is C11H15N2O8P, its molecular weight is 334.2. NMN occurs naturally in the human body and is also abundant in some fruits, vegetables and meats.
Studies have found that the greatest role of nmn is that NMN is a precursor of NAD+, which can increase the level of NAD+ in the body. NAD+ is a coenzyme required by biological tissues. It plays the role of transferring hydrogen, activating multi-enzyme systems, promoting the synthesis and metabolism of nucleic acids, proteins, and polysaccharides, improving material transport and regulation control, and improving metabolic functions in the process of biological oxidation.
Studies have found that the greatest effect of NMN is that it is a precursor substance of NAD+, which can enhance the level of NAD+ in the body. NAD+ is a necessary coenzyme in biological tissues, which plays a role in transferring hydrogen, activating multi-enzyme system, promoting synthesis and metabolism of nucleic acid, protein and polysaccharide in the process of biological oxidation, and improving substance transport and regulation control. The effect of improving metabolic function.
With age, the level of NAD+ gradually decreases, and the cell reaction and metabolism weaken, which brings some problems, such as long wrinkles, hair loss, poor energy, fatigue, etc. Through NMN (W+NMN25000) to increase the level of NAD+ in the body, it can supplement physical strength, anti-oxidation, and increase cellular ATP energy. Scientists have shown that NMN has the following effects.
With the increase of age, the level of NAD+ is gradually decreased, and the cell reaction and metabolism are weakened, which brings some problems, such as wrinkles, hair loss, poor energy, fatigue, etc. NMN (W+NMN25000) is used to improve the level of NAD+ in the body, which can supplement physical strength, antioxidant, improve the energy of ATP cells, etc.
What are the health , and what are the effects of nmn?
1. Repair cells
NMN is the precursor substance of NAD+ mitochondria, it is difficult to ingest in daily life, and it can also help us prolong life, so many people are now supplementing this product to repair cells. Nmn can be supplemented in our daily life. It is widely found in various vegetables, but its content is very small, and there is no way to make up for the body's needs.
Research studies have shown that the digestive system of the human body can absorb NMN intact. 2~3 minutes after entering the human body, NMN can be transported into the blood, and rapidly increase the NMN level of various organs and tissues.
The anti-aging difference between W+NMN and NMN is : The cell enhances the repairing
With the increasing maturity of W+NMN technology, research on new-generation technologies such as exosomes and cytokines has been derived. Cytokines are polypeptide substances secreted during the growth of W+NMN culture. Common members include EGF, bFGF, TGF-β, NGF, VEGF, etc., which promote fibroblast metabolism, collagen regeneration and tissue repair.
In human skin, there are many collagens that connect cells and support the skin structure, which is the key to making the skin plump, delicate and smooth. W+NMN wakes up and repairs damaged skin cells, improves cell rejuvenation ability; enhances the self-regulation ability of the endocrine system, repairs the skin's water retention performance, reduces the appearance of wrinkles, and keeps the skin tender and smooth; at the same time improves cell circulation
W+NMN can awaken and repair damaged skin cells and enhance their ability to reproduce, Enhance the internal secretion system's self-regulation ability, repair the skin's water retention performance, so that the skin can reduce the generation of wrinkles, keep delicate and smooth; At the same time improve the cell circulation.
After W+NMN acts on the face, the facial skin secretes collagen, hyaluronic acid, elastic fibers and other substances, making the skin firm, white and lustrous, diluting pigmentation, and repairing sensitive skin damage caused by air pollution and ultraviolet radiation.
W+NMN is the fundamental cell for rejuvenation and restoration of youthful appearance, providing a sufficient source for cell renewal and rejuvenation of the skin system. The cell metabolism of Xinsheng is strong, it can discharge waste in time, prevent the deposition of skin pigment, inhibit and reduce the formation of spots; the young cells differentiated by Xinsheng have better water retention, which is enough to restore the delicate and smooth aging skin; at the same time, synthesize a large amount of collagen and elastin, restore skin elasticity, reduce wrinkles, and fundamentally improve and repair the quality of the skin system. Read the article: What is the health care effect of nmn, the role of nmn!
2. The degree of rejuvenation of human physiological indicators by W+NMN
1. The benefits of W+NMN on the brain:
Current research focuses on the ability of PQQ to protect memory and cognition in aged animals and humans in W+NMN. Here are some of the effects noted in animal studies involving PQQ: Blocks the formation of several compounds that are harmful to brain cells. Protects against autooxidation of the D-1 gene, an early step in the pathogenesis of Parkinson's disease. Protects brain cells from oxidative damage. Reverses cognitive impairment caused by chronic oxidative stress and improves performance on memory tests in animal models of diet. Protects the brain from the neurotoxicity of glutamate, mercury, amine oxide (a potent neurotoxin used by scientists to induce Parkinson's disease in laboratory animals), and other potent toxins. Prevents the development of a protein associated with Parkinson's disease. Protects nerve cells from damage from the beta-amyloid protein associated with Alzheimer's disease.
2. W+NMN on neuron protection and cognitive function:
Cognitive decline is one of the many symptoms of aging, and modulation of human neurogenesis may be a therapeutic strategy to overcome this condition.
The team of scientists tested W+NMN and found that the molecule can protect the nervous system and improve cognition.
The researchers boosted NAD+ levels with W+NMN, a compound that acts as an NAD+ booster to improve brain energy metabolism, and found that the compound restored cognition in a rat model. This restoration came from a modification of neuronal survival and metabolism, as well as a reduction in cellular stress. In this study, W+NMN modified the cognitive abilities of rats with Aβ oligomers, and after treating the rats with Aβ oligomers, the team also found that the animals' neuronal death was significantly reduced. After 48 hours of incubation, diseased rats treated with W+NMN had about a 65 percent reduction in cell death compared to untreated animals .
The scientists also found that W+NMN treatment reduced neuronal cell death in hippocampal slices (specimens taken from the brain). Reduces cellular stress in neurons by reducing reactive oxygen levels (levels of chemically reactive molecules that contain oxygen) in the brains of rats affected by the disorder.
In addition to finding cognitive modification and reduced neuronal death, the researchers also found lower levels of cellular stress in the treated rat model, suggesting a neuroprotective effect of W+NMN. However, protection was reversed when NMN-derived NAD+ was inactivated.
After a lot of experiments, W+NMN can:
super brain nutrition
basic anti -aging
rejuvenate nerve cells
Neuron protrusion, nerve cell strengthening
protect brain cells
Prevent neuronal apoptosis
reduce neuroinflammation
Metabolic amyloid beta accumulation
Improve memory and learning
3. The activity of brain vascular cells after W+NMN modified diet oxidative stress
In experiments, the team found that NMN protected mouse endothelial cells grown in laboratory dishes treated with the oxidative stress-inducing molecule hydrogen peroxide. Treatment with hydrogen peroxide for 12, 24 and 48 hours resulted in a progressive decrease in cell viability. Even more, additionally increasing the supplemental concentration of NMN (300 to 500 M) promoted better cell proliferation rates. These results suggest that NMN can reverse the deleterious effects of oxidative stress on brain endothelial cells caused by metabolic disorders such as diabetes.
4. W+NMN enhances mitochondrial health after oxidative stress
To find out whether the NMN-induced increase in cell survival came from improved dietary mitochondrial health, the scientists examined the structural integrity of mitochondrial membranes. After the harmful hydrogen peroxide treatment, they found that the mitochondrial membrane was more permeable, indicating reduced structural integrity. Addition of NMN to the hydrogen peroxide treatment restored mitochondrial membrane potential, suggesting restoration of mitochondrial health. These results suggest that NMN increases cell survival under oxidative stress by improving the integrity and health of mitochondrial membranes.
NMN protects against oxidative stress-induced mitochondrial damage. The ratio of red to green fluorescence indicates mitochondrial membrane permeability—the ability of ions to pass through the mitochondrial membrane. Higher ratios represent lower membrane permeability, indicating greater structural integrity. In this experiment, NMN restored the structural integrity of mitochondrial membranes after treating cells with hydrogen peroxide, a molecule that triggers oxidative stress. Read the article: What is the health care effect of nmn, the role of nmn!
5. The effect of W+NMN on cellular pathways
To clarify how NMN rescues cells from the toxic effects of oxidative stress, the researchers examined levels of the proteins NF-ĸB and NAMPT, as their levels fluctuate with inflammation and disease. NF-ĸB is a protein complex that coordinates the immune response and the cellular response to oxidative stress, while NAMPT is the enzyme in cells that synthesizes NMN from nicotinamide. Luo and colleagues found that NMN increased NAMPT levels and decreased NF-ĸB levels after hydrogen peroxide treatment. Changes in NAMPT and NF-ĸB levels indicated that NMN treatment modified NAD+ biosynthesis and reduced inflammation, respectively. This insight could help researchers understand the cellular mechanisms by which NMNs function, leading to better therapeutics targeting these cellular pathways.
NMN treatment of mouse brain endothelial cells leads to reversal of oxidative stress-induced NAMPT and NF-KB effects. Treatment with hydrogen peroxide, which induces oxidative stress, resulted in decreased NAMPT levels, whereas NMN reversed these effects. Hydrogen peroxide treatment promoted a significant increase in NF-KB levels, whereas addition of NMN reversed this effect.
Taken together, our results suggest that NMN has the ability to protect H2O2-bEnd.3 cells from apoptosis by regulating NAMPT enzyme and NF-ĸB p65 signaling pathway," read the article: What is the health care function of nmn, the role of nmn!
When it comes to NMN, everyone already knows
But when it comes to the black gold version of W+NMN 25000, everyone only knows that it is good.
What's so good about it? Many people don't necessarily know (the difference between W+NMN black gold version and NMN)
Today we will take stock of the new standard of the Japanese W+NMN 25000 black gold version :
1. High absorption and utilization rate
From level 1 to level 15 purification, the human affinity and utilization rate reached the peak, realizing a major leap from a single component NMN to a compound component type W+NMN, greatly improving the conversion efficiency of NAD+, and also changing the disadvantages of low absorption and single function of traditional NMN products. W+NMN has the technology to clean up the obstacles that hinder the release of NMN in the body.
After supplementation, it can stimulate the biosynthesis of mitochondria by stimulating the PGC-1α, TFAM pathway, and cAMP response element binding protein pathway, and can strengthen and restore the function of mitochondria and repair abdominal damage, and finally express a variety of beneficial effects on the body;
2. High energy efficiency and excellent resilience
Japan's W+NMN25000 black gold version's super high-quality compound ingredients work together to maintain a high balance of ingredients.
PQQ stimulates mitochondria, maintains brain function and prevents brain aging diseases, strengthens neurons and brain nerve nutrition, improves peroxidative damage in biological organisms, has a wide range of biological activities such as catalyzing redox reactions, promoting mitochondrial generation, regulating energy metabolism, and regulating cell signaling pathways. The United States and the European Union have listed it as a high-safety dietary supplement.
As a rare natural antioxidant, ERGO has strong stability and is an important physiologically active substance in the body. It plays a role in removing bacilli, regulating intracellular redox reactions, and participating in the regulation of intracellular energy.
PLAS plays an important role in the living body, and it is one of the main components of the cell membrane. There are reports that it can protect nerves, form myelin, stabilize the flow of cell membranes, store polyunsaturated fatty acids, and help conduct signals.
Oxidative damaged PC12 nerve cells, it was found that it can significantly increase the survival rate of PC12 cells, and also restore the cell shape;
3. High standard execution
Japan is the only country in the world that listed NMN as a legal drug and food raw material, and took the lead in conducting clinical trials; Japanese officials have perfect requirements and strict supervision on the production specifications, safety, purity requirements, and testing methods of NMN raw materials and products.
GRAS certified raw materials
GMP pharmaceutical grade production
Refined component analysis
SGS strict testing
4. Laboratory-grade raw materials, black gold version 25000 more reliable double + bio-enzymatic extraction
The most active form of nicotinamide mononucleotide, W+NMN capsules are high-quality NMN25000, using laboratory-grade raw materials for production, and obtaining high-quality NMN raw materials through continuous optimization of the production process. Using sophisticated detection methods to ensure high density and high content, and to carry out clinical experiments to verify safety and efficacy.
Using cutting-edge technology: double + enzymatic evolution technology, full enzymatic preparation, W + NMN25000 black gold version has a purity of more than 99%, and has better biological activity.
5. Five-level enhanced boost: Four protection technologies enable the complete release of NMN in the body,
1) Super boost boost: converted into NAD+;
2) Level-enhancing boost: promote the consumption of the enzyme PARP;
3) Level-strengthening boost: Regulate Sirtuins fine bud longevity protein;
4) Level-up boost: release the NMN essential wake-up agent W+NMN (telomere tower) to wake up the dormant NMN in the body. Studies have shown that Slc12a8 in the small intestine plays an important role in transporting NMN from the intestine to circulation, affecting NAD+ levels in the small intestine and systemic NMN supply in vivo.
5) Level-enhanced boosting: four core regulatory factors, and are directly related to mitochondrial production and function improvement, strengthening and restoring mitochondrial function and repairing abdominal damage; read in one article: what is the health care function of nmn, and the role of nmn!
Multinational authoritative clinical verification report released:
The difference between the W+NMN black gold version and ordinary NMN, after the upgrade of the W+NMN black gold version ,
1. The degree of rejuvenation of human physiological indicators by W+NMN
Eliminate senescent cells (zombie cells)
The latest aging biology textbook in 2019 summarizes decades of aging research and attributes the mechanism of aging to two major problems: oxidative self-oil damage and a decline in NAD+ levels.
A review was published, which introduced that after 12 days of use, senescent cells (zombie cells) were reduced by 18%, and W+NMN can reduce human senescent cells (zombie cells) by 37% for one year.
W+NMN inhibits its own senescent cells, improves the cognitive senescent cells of aged mice, and slows down the process of senescent cells evolving into senescent cells. Stimulate cell proliferation and growth factors to promote the repair and rejuvenation of aging tissues.
2. The degree of rejuvenation of human physiological indicators by W+NMN
W+NMN protects the heart from oxidative damage:
The protective effect of PQQ on the heart is related to the ability of empathy to remove from the oil base. PQQ can eliminate reactive oxygen species (ROS) produced by hypoxia-reperfusion, and significantly reduce the release of dehydrogenase in the heart. Under the catalysis of flavin reductase, its catalytic product can also reduce the peroxidation state of hemoglobin, and eliminate the damage to the myocardium caused by hypoxia-reperfusion. Studies have shown that the use of PQQ to protect the heart of ischemia-reperfusion mice significantly reduced the size of myocardial infarction, enhanced left ventricular pressure and left ventricular diastolic pressure rise and fall rate, reduced ventricular fibrillation, and reduced the level of malondialdehyde in myocardial tissue. PQQ can also inhibit the generation of ROS induced by hydrogen peroxide in rat cardiomyocytes and the reduction of mitochondrial membrane potential, thereby reducing oxidative stress, inhibiting the inactivation of mitochondrial function, and protecting rat cardiomyocytes.
W+NMN prevents liver damage:
Experimental liver injury in rats caused by toxins such as carbon tetrachloride (C), hemisaccharamine, and acetamide sulfide can be prevented by pre-injecting a certain dose of PQQ and its derivatives intraperitoneally. PQQ can reduce the generation of ROS caused by hepatotoxic substances, significantly reduce the levels of serum bilirubin alanine aminotransferase (glutaic pyruvic transainese, GPT) and dehydrogenase, block liver cell necrosis, and does not affect the conventional biochemical indicators of rats (such as blood sugar, blood and urine nitrogen, etc.).
W+NMN has dual biological functions of neuron nutrition and neuroprotection
It plays an important regulatory role in the growth, development, differentiation, regeneration and specific expression of biological functions of the middle bundle and peripheral neurons. Experiments have shown that in vitro, PQQ can stimulate LM cells and Schwann cells to produce NGF. Read the article: What is the health care function of nmn, and the role of nmn!
3. The degree of rejuvenation of human physiological indicators by W+NMN
As a rare natural oxidant, ERGO has strong stability and is an important physiologically active substance in the body. It plays a role in removing oil, regulating intracellular redox reactions, and participating in the regulation of intracellular energy.
ERGO is a naturally occurring food-derived oxidant. Despite its strong hydrophilicity, ERGO is readily absorbed from the gastrointestinal tract and distributed to various organs including the brain. This is mainly because its entry into brain cells is mediated by the ERGO-specific transporter OCTN1/SLC22A4. Octn1 knockout mice lack ERGO in the brain due to the absence of Octn1 in neurons, neurorod cells, and microglia.
The presence of OCTN1 and the uptake of ERGO by brain parenchymal cells may indicate that ERGO and its transporters play critical roles in brain function. Oral administration of ERGO has antidepressant activity in mice. Furthermore, repeated oral administration of ERGO enhanced memory function in mice and humans, respectively.
ERGO also prevented stress-induced sleep disturbances and neuronal damage caused by amyloid-beta in rodents. In vitro observations suggest that ERGO benefits brain function through its oxidative activity and promotion of neurogenesis and neuronal maturation. This review discusses the possible involvement of ERGO in brain function and its potential therapeutic properties.
The protective effect of W+NMN on cells:
ERGO is a powerful hypoxenic acid scavenger (HOCl), and while many compounds react with hypoxic acid, few react as rapidly as ERGO. a 1-Antiprotease inhibitors (API), such as elastase, are particularly sensitive to hypoxic acid, and ERGO at physiological concentrations can effectively protect the API against the inactivation effect caused by hypoxic acid. Since neutrophils are the main source of hypoxic acid in the body, one of the functions of ERGO is to protect red blood cells from the harm of neutrophils from normal functions or pathological inflammatory sites.
Women: Anti-aging by improving the function of rod cells after W+NMN upgrade
The dermal rod cells help produce substances such as collagen, but the dermal rod cells decline with age. Therefore, in the treatment in recent years, the anti-aging treatment is carried out by oral administration of fibroblasts of W+NMN. The dermis cells and fibroblasts exist in the dermis deep in the skin.
The doctor pointed out that because of its powerful functions of redifferentiation and immune regulation, NMN has the effect of rejuvenating the face, delaying the decline of organ and tube function, and improving the body's resistance.
Women: W+NMN and diet modification for women's body functions
Associated with loss of oocyte mass, reproductive senescence in female RU mammals is an irreversible process accompanied by a decrease in NAD+ levels (Bertoldo et al., 2020). However, NMN administration is expected to restore oocyte quality and fertility in aged mice and reverse the adverse effects of maternal age on developing embryos, suggesting that NMN can rescue female reproductive function in mammalian RU animals (Bertoldo et al., 2020). Read the article: What is the health care effect of nmn, the role of nmn!
Men: W+NMN research on preventing alcohol-induced liver damage
Stimulation of the SirT1/PGC-1α/mitochondrial biosynthesis pathway attenuates alcohol-induced liver injury; over time, excessive alcohol intake leads to disease, which usually does not cause many symptoms in the early stages but still produces severe liver damage. This alcohol-induced damage arises from three factors: inflammation, metabolic dysfunction and oxidative stress -- the buildup of compounds called reactive oxygen species that damage cells, proteins and DNA.
In this study, W+NMN was shown to protect against alcohol-induced liver damage. In the study, Atf3 activity increased approximately 40-fold in those who did not receive NMN compared to those who did not drink alcohol. Although it did not completely moderate Atf3 overexpression, NMN improved it significantly, as NMN injectors reduced this activity by about 5-fold.
The research team believes that NMN prevents the uncontrolled accumulation of scar tissue called fibrosis in the liver and also lessens the damaging effects of alcohol on the liver. For the average adult who drinks slightly above the recommended amount of alcohol, once more than two drinks, enhancing liver function with NMN supplementation may be a beneficial way to promote liver health.
The key substance to accelerate the metabolism of alcohol is NAD+. NAD+ is a substance that is inherent in the human body and will be slowly lost with the growth of physiological age. NMN is the direct precursor of coenzyme I (NAD+). Taking NMN before and after drinking alcohol can quickly increase the NAD+ content in the body in about 15-30 minutes. NAD+ is specially used to cut hydrogen ions, and take away a few electrons by the way. Two-step interception, alcohol becomes the fuel of life, even if the amount of alcohol is doubled, there will be no headaches.
Men: W+NMN restores the function of men
In foreign countries, the supplement, NAD+ precursor NMN has become a means of restoring the functional role of men. Increased NAD+ can increase the synthesis of neurotransmitter dopamine and improve male function. NMN has been proven to be an effective way to quickly increase NAD+, and it is more convenient to use than other NAD+ precursors. Since NMN is the body's own substance, it is also very safe. There are several friends around me who have experienced emotional change and even joyful experience within a short period of time after using NMN.
Therefore, after taking W+NMN, the NAD+ level of the human body can be increased, dopamine can be increased, the vitality of the nervous system can be enhanced, the mood and mental state can be improved, the depression and depression can be relieved, and the loss of sexual interest and sexual ability caused by long-term emotional depression can be avoided, and the performance of sexual life can be improved by increasing the excitability of emotions.
NMN substances can indeed play an obvious anti-aging effect, delay the speed of aging, and effectively improve the body's comprehensive immunity, making the body younger. NMN anti-aging is a collision between technology and life, and it is worth trying for every serious life. ~ MM ~ One article to understand: What is the health care effect of nmn, the role of nmn!