Is nmn science or IQ tax, nmn new news! Since NMN was circulated in the Chinese market, the question of its being an "IQ tax" has never stopped. After all, regardless of the improvement effect of NMN on various chronic diseases of the elderly discovered by scientists in recent years, the anti-aging effect alone is amazing enough.
So is NMN an IQ tax? Judging from the various information currently available, the answer is no. Japan's W+NMN terminal tower 25000 is analyzed from three aspects:
So is NMN an IQ tax or not? According to the information available, the answer is no. Japanese W+NMN terminal Tower 25000 is analyzed from three aspects:
1. From a scientific point of view, nmn is not an IQ tax
Different from the previous "folk rumors" and "ancestral secret recipes", NMN was born in Zhengmiaohong, is the result of modern life science research, and has many authoritative research endorsements.
Since Sinclair, a professor at Harvard Medical School, discovered the efficacy of NMN in 2013, many scientists from China, the United Kingdom, Germany, and Japan have carried out related experimental research on NMN. This has not only verified the anti-aging efficacy of NMN, but also discovered many other efficacy of NMN, providing modern medicine with many new ideas for the treatment of difficult and miscellaneous diseases.
At present, there are hundreds of research papers related to NMN in well-known scientific journals such as "Cell", and this number is constantly refreshing. So far, NMN users have exceeded one million people, so NMN is not an IQ tax. Is nmn science or IQ tax, nmn new news!
2. From the perspective of market economy
NMN is a supplement product that is popular all over the world to improve aging problems. It has a huge market in the world. Some people have predicted that the market size will reach 600 billion US dollars in five years. At present, NMN is favored by capital in my country and even in the world, and many well-known rich people have invested in the NMN industry.
At the same time, unlike the so-called "health care products" that can be seen everywhere in convenience stores next to the streets and alleys in the past, the price of NMN products is generally more than 1,000 yuan, which is not cheap. According to user portrait data, the main consumer groups of W+NMN Duanli Tower 25,000 in Japan are middle and high-income groups from first- and second-tier cities, and people know that most of these groups belong to the "elite" group and have a relatively high level of knowledge, so they will not be easily deceived. Here we can also see the scientific nature of NMN efficacy from the side.
From 2022, all W+NMN certified by OULF will be made in Japan, and those from other places will be counterfeit. Please look for the 25000 regular product guarantee of Japan's W+NMN terminal tower .
From 2022, all W+NMN products certified by OULF will be of Japanese origin, while those from other regions will be counterfeits. Please look for Japan W+NMN terminal tower 25000 standard product guarantee.
3. From the perspective of media reports
Browsing the relevant reports about NMN on various social platforms, it is generally "mixed". However, it can be clearly found that even the articles with "disclosure" and "criticism" are aimed at the chaos of the NMN market and industry, rather than criticizing NMN itself.
The People's Daily, a well-known official media in my country, carried out a large number of reports on the effectiveness of NMN in September this year, with the proportion of the article as high as 58%, which can be regarded as the official rectification of NMN.
When people question NMN as an "IQ tax", they usually link it with health care products that were previously popular in the Chinese market. But things are constantly developing, and people should look at problems dialectically from a developmental perspective, and not “one size fits all”. What’s more, from multiple perspectives, the statement that NMN is an “IQ tax” is simply untenable. Is nmn science or IQ tax, nmn new news!
The rise of NMN as an industry of anti-aging health care products reflects from another aspect that consumers’ demand for health care products is no longer simple health care and nutritional supplements, but more pursuit of in-depth improvement of products.
Anyone with a little knowledge of biochemistry knows that the energy generated in eukaryotic organisms mainly depends on the tricarboxylic acid cycle, and the nutrients ingested by our body need to be converted into energy (ATP) through metabolic pathways. In this biochemical reaction, NAD+ is a coenzyme that plays an important role in many links. It participates in thousands of different chemical reactions in cells and is an important source of cell vitality.
In these thousands of reactions, NAD+ as a coenzyme participates in energy synthesis; on the other hand, as a substrate, NAD+ participates in regulating cell survival and apoptosis, DNA repair, immune response and other physiological functions. The NMN mentioned above can help produce NAD+.
NAD+ is a coenzyme that plays an important role in many links. It participates in thousands of different chemical reactions in cells and is an important source of cell viability. And that NMN, that's what's going to help produce NAD plus.
That is, NMN helps produce NAD+, which drives the body's energy production. With age, many substances in the human body will decrease, just like our calcium will be lost. Therefore, supplementing Japan's W+NMN terminal tower 25,000 to help the production of NAD+ has become one of the available ways.
In 2023, the efficacy of NMN will hit a new high in medical research. The application field of NMN is not only anti-aging for genes
Traditional NMN is only limited to gene anti-aging in the practical field, but it is far from enough as the aging process of the body changes the activity of genes. There is also basic energy to satisfy the activity of genes, and there are also repair factors to target damaged cells for renewal and iteration.
In the practical field, traditional NMNS are only limited to the anti-aging of the basic causes. However, as the aging process of the body changes the activity of the basic causes, it is far from enough. There are also basic energies to meet the activity of the basic causes, and repair factors should be targeted to locate the damaged cells for renewal and iteration.
After 6 upgrades , the Japanese W+NMN terminal tower 25000 has become the original basic function for gene anti-aging . The upgraded W+NMN terminal tower focuses on neuron repair , brain atrophy, brain anti- aging, and brain nerve repair :
After 6 upgrades, W+NMN has become the original basic function of fundamental anti-aging. The upgraded black gold version W+NMN25000 focuses on neuron repair, brain atrophy, brain anti-aging, and brain nerve repair:
Breaking through the perennial medical bottleneck, brain cells have always been non-renewable, and neuron repair has always been a medical problem. The black gold version of W+NMN uses the basic functions of NMN to open up the gene chain and combines four brain nerve restoration elements: neurorestoration (W+NMN principle) nerve regeneration, nerve repair or replacement, neural remodeling, neuromodulation, and neurorehabilitation, which can be used as a neurorestorative intervention method (W+NMN principle).
Black gold version of W+NMN through the basic function of NMN, break through the causal chain, combined with four brain nerve restoration elements: neurorehabilitation (W+NMN rule) nerve regeneration, nerve repair or replacement, nerve replastic, nerve regulation, nerve rehabilitation, can be used as a neurorehabilitation intervention method (W+NMN rule).
Reversal of brain aging targets aging neuron cells and brain cells, through W+NMN25000 black gold version super-optimized compound component synergy technology to respectively activate nucleus activation, cell source activation and necrotic cell renewal, and at the same time continue to appeal to the brain for brain cell regeneration energy and neuron regeneration energy to gradually restore the vitality of brain cells and neurons. This product has a good performance for mental and mental workers, brain fatigue, neurasthenia anxiety, insomnia, and the improvement of forgetfulness in the elderly.
After the upgrade, the corresponding effects and functions of the ingredients of the Japanese W+NMN end tower 25000 black gold version :
PQQ
1. Help promote brain function and prevent brain aging diseases
2. It also has a strong ability to scavenge free radicals, which is equivalent to 50-100 times that of ascorbic acid
3. Protects the Heart from Oxidative Damage
4. Promote nerve growth and protect the nervous system
5. Prevention and treatment of liver damage
6. May improve mitochondrial density and function
7. Improve the reproductive outcome of animals (lack of PQQ may lead to abnormal reproductive ability)
Studies have also found that PQQ also promotes the activity of life-extending transcription factors, protects your brain cells and their DNA from damage, and activates the natural repair functions of your mitochondria, all while including improvements in cognition, learning and memory, and a reduced risk of neurodegeneration. Studies have shown that PQQ can protect and improve the survival rate of neurons by stimulating the synthesis of nerve growth factor (NGF) in certain glial cells in the central nervous system. Is nmn science or IQ tax, nmn new news!
ERGO
1. Maintain DNA biosynthesis
2. Maintain normal cell growth
3. Maintain cellular immune function
4. Improve the vitality of cerebrovascular cells after oxidative stress
In their experiments, the team found that ERGO promoted better cell proliferation rates and increased mitochondrial health and vitality. Increases cell survival under oxidative stress. Studies have shown that ERGO is highly effective in preventing neurodegenerative diseases such as dementia and Alzheimer's disease.
PLAS
PLAS is a phospholipid present in almost all human tissues, with high concentrations in the brain. It plays a very important role in brain function and has brain-stimulating activities, including:
1. Promoting brain cell proliferation
2. Protect brain cells from oxidation
3. Inhibition of amyloid accumulation that can cause brain cell death
4. Protect brain cells from death
5. Auxiliary learning and memory function
The scientists also found that if the subjects' PLAS levels were lower than 75 percent of normal, cognitive function would also decline. Lack of PLAS may lead to synaptic dysfunction and neurotransmitter depletion latent in Alzheimer's disease. Is nmn science or IQ tax, nmn new news!
When it comes to NMN, everyone already knows
But when it comes to the black gold version of the W+NMN terminal tower 25000, everyone only knows that it is good
What's so good about it? Many people don't necessarily know (the difference between W+NMN black gold version and NMN)
Today we will take stock of the new standard of the Japanese W+NMN terminal tower 25000 black gold version :
1. High absorption and utilization rate
From level 1 to level 15 purification, the human affinity and utilization rate reached the peak, realizing a major leap from a single component NMN to a compound component type W+NMN, greatly improving the conversion efficiency of NAD+, and also changing the disadvantages of low absorption and single function of traditional NMN products. W+NMN has the technology to clean up the obstacles that hinder the release of NMN in the body.
After supplementation, it can stimulate the biosynthesis of mitochondria by stimulating the PGC-1α, TFAM pathway, and cAMP response element binding protein pathway, and can strengthen and restore the function of mitochondria and repair abdominal damage, and finally express a variety of beneficial effects on the body;
2. High energy efficiency and excellent resilience
Japan's W+NMN25000 black gold version's super high-quality compound ingredients work together to maintain a high balance of ingredients.
PQQ stimulates mitochondria, maintains brain function and prevents brain aging diseases, strengthens neurons and brain nerve nutrition, improves peroxidative damage in biological organisms, has a wide range of biological activities such as catalyzing redox reactions, promoting mitochondrial generation, regulating energy metabolism, and regulating cell signaling pathways. The United States and the European Union have listed it as a high-safety dietary supplement.
As a rare natural antioxidant, ERGO has strong stability and is an important physiologically active substance in the body. It plays a role in removing bacilli, regulating intracellular redox reactions, and participating in the regulation of intracellular energy.
PLAS plays an important role in the living body, and it is one of the main components of the cell membrane. There are reports that it can protect nerves, form myelin, stabilize the flow of cell membranes, store polyunsaturated fatty acids, and help conduct signals.
Oxidative damaged PC12 nerve cells, it was found that it can significantly increase the survival rate of PC12 cells, and also restore the cell shape;
3. High standard execution
Japan is the only country in the world that listed NMN as a legal drug and food raw material, and took the lead in conducting clinical trials; Japanese officials have perfect requirements and strict supervision on the production specifications, safety, purity requirements, and testing methods of NMN raw materials and products.
GRAS certified raw materials
GMP pharmaceutical grade production
Refined component analysis
SGS strict testing
4. Laboratory-grade raw materials, black gold version 25000 more reliable double + bio-enzymatic extraction
The most active form of nicotinamide mononucleotide, W+NMN capsules are high-quality NMN25000, using laboratory-grade raw materials for production, and obtaining high-quality NMN raw materials through continuous optimization of the production process. Using sophisticated detection methods to ensure high density and high content, and to carry out clinical experiments to verify safety and efficacy.
Using cutting-edge technology: double + enzymatic evolution technology, full enzymatic preparation, W + NMN25000 black gold version has a purity of more than 99%, and has better biological activity.
5. Five-level enhanced boost: Four protection technologies enable the complete release of NMN in the body,
1) Super boost boost: converted into NAD+;
2) Level-enhancing boost: promote the consumption of the enzyme PARP;
3) Level-strengthening boost: Regulate Sirtuins fine bud longevity protein;
4) Level-up boost: release NMN essential wake-up agent W+NMN (end tower) to wake up dormant NMN in the body. Studies have shown that Slc12a8 in the small intestine plays an important role in transporting NMN from the intestine to circulation, affecting NAD+ levels in the small intestine and systemic NMN supply in vivo.
5) Level-enhancing boost: four core regulatory factors, and are directly related to mitochondrial production and function improvement, strengthening and restoring mitochondrial function and repairing abdominal damage; nmn is science or IQ tax, nmn new news!
Multinational authoritative clinical verification report released:
The difference between the Japanese W+NMN side tower black gold version and ordinary NMN, after the upgrade of the W+NMN black gold version ,
1. The degree of rejuvenation of human physiological indicators by W+NMN towers in Japan
Japan W+NMN in terms of brain function in changing diet:
PQQ itself has a certain effect, and it was further confirmed in a human double-blind, placebo-controlled clinical trial conducted in Japan on 19th, 2007. In this study, 71 middle-aged and elderly adults, aged 40-70, supplemented with 20 mg of PQQ daily showed higher improvements in cognitive function tests compared to the placebo group, but the results were more pronounced in the group that received 20 mg of PQQ and 300 mg of CoQ10. Both PQQ and CoQ10 are involved in mitochondrial energy production, so these results are not surprising.
Japanese W+NMN stimulates mitochondria, maintains brain function and prevents brain aging diseases:
Compelling evidence shows that PQQ is essential for healthy cellular function. Through its ability to stimulate mitochondrial biogenesis, PQQ supports healthy aging and helps protect cells from damage that leads to loss of function in the elderly. Increased intake of PQQ has been shown to enhance healthy brain function and may prevent age-related cognitive loss, including stroke or Alzheimer's disease. Since PQQ is not produced in the body, bismuth needs to be obtained from the diet or through supplements.
Japan W+NMN prolongs service life:
The way PQQ promotes mitochondrial growth has been shown to have extraordinary additional efficacy effects. Supplementation with PQQ turns on gene expression pathways regulated by PGC-1a, a well-known stimulator of mitochondrial biogenesis. This appears to be done by activating SIRT1, a sirtuin regulator protein. Many recent studies have shown that sirtuins help regulate cellular health, prevent disease and age-related loss of function, and play a role in extending lifespan.
In other words, PQQ not only triggers mitochondrial biogenesis, it also stimulates and supports many other protective mechanisms associated with lifespan extension and health.
In addition to all these effects, as an antioxidant, PQQ also removes harmful free radicals. Many other nutrients can only quell oxidative stress for a short period of time. For example, vitamin C can only participate in the beneficial redox cycle of about four cycles. In comparison, one PQQ molecule can go through a staggering 20,000 cycles!
Thanks to all these abilities, PQQ has proven that it can prolong life. The worm (C. elegans) is an animal model commonly used to study longevity because of its relatively short lifespan. Two different research groups used the model to assess the life-extending effects of PQQ.
In both studies, supplementation with PQQ resulted in a significant increase in the average lifespan of the treatment animals. In fact, the studies had nearly identical results, with one study increasing life expectancy by an average of 30 percent, while the other increased lifespan by 31 percent.
Dr. Ames is a widely respected professor emeritus of biochemistry at UC Berkeley and has also worked at the National Institutes of Health. Dr. Ames writes frequently about nutrients that extend life and improve diet health. Dr. Ames included PQQ on his short list of "longevity vitamins" based on its ability to stimulate mitochondrial biogenesis. Is nmn science or IQ tax, nmn new news!
Effects of cerebrovascular cells on oxidative stress after Japanese W+NMN dietary modification
In experiments, the team found that NMN protected mouse endothelial cells grown in laboratory dishes treated with the oxidative stress-inducing molecule hydrogen peroxide. Treatment with hydrogen peroxide for 12, 24 and 48 hours resulted in a progressive decrease in cell viability. Even more, additionally increasing the supplemental concentration of NMN (300 to 500 M) promoted better cell proliferation rates. These results suggest that NMN can reverse the deleterious effects of oxidative stress on brain endothelial cells caused by metabolic disorders such as diabetes.
W+NMN enhances mitochondrial health after oxidative stress
To find out whether the NMN-induced increase in cell survival came from improved dietary mitochondrial health, the scientists examined the structural integrity of mitochondrial membranes. After the harmful hydrogen peroxide treatment, they found that the mitochondrial membrane was more permeable, indicating reduced structural integrity. Addition of NMN to the hydrogen peroxide treatment restored mitochondrial membrane potential, suggesting restoration of mitochondrial health. These results suggest that NMN increases cell survival under oxidative stress by improving the integrity and health of mitochondrial membranes.
NMN protects against oxidative stress-induced mitochondrial damage. The ratio of red to green fluorescence indicates mitochondrial membrane permeability—the ability of ions to pass through the mitochondrial membrane. Higher ratios represent lower membrane permeability, indicating greater structural integrity. In this experiment, NMN restored the structural integrity of mitochondrial membranes after treating cells with hydrogen peroxide, a molecule that triggers oxidative stress.
2. The degree of rejuvenation of human physiological indicators by W+NMN terminal tower in Japan
Eliminate senescent cells (zombie cells)
The most well-known benefit of W+NMN is its effect on promoting longevity. Energy production and mitochondrial function decline with age, due in large part to the parallel decline of NAD in various cells and organs in the body.
Senescent cells are eventually lodged into cellular senescence, which means cells stop dividing and losing function: Senescence plays an important role in the process of aging and disease. The effects of cellular senescence can be mitigated by increasing NAD levels with supplementation of W+NMN.
Since NMN is the main precursor of NAD, supplementing with W+NMN is a beneficial way to reduce the cellular and mitochondrial decline and dysfunction that occurs with age.
3. The rejuvenation degree of the Japanese W+NMN terminal tower on the physiological indicators of the human body
Japanese W+NMN protects the heart from oxidative damage:
The protective effect of PQQ on the heart is related to the ability of empathy to remove from the oil base. PQQ can eliminate reactive oxygen species (ROS) produced by hypoxia-reperfusion, and significantly reduce the release of dehydrogenase in the heart. Under the catalysis of flavin reductase, its catalytic product can also reduce the peroxidation state of hemoglobin, and eliminate the damage to the myocardium caused by hypoxia-reperfusion. Studies have shown that the use of PQQ to protect the heart of ischemia-reperfusion mice significantly reduced the size of myocardial infarction, enhanced left ventricular pressure and left ventricular diastolic pressure rise and fall rate, reduced ventricular fibrillation, and reduced the level of malondialdehyde in myocardial tissue. PQQ can also inhibit the generation of ROS induced by hydrogen peroxide in rat cardiomyocytes and the reduction of mitochondrial membrane potential, thereby reducing oxidative stress, inhibiting the inactivation of mitochondrial function, and protecting rat cardiomyocytes.
Japanese W+NMN prevents liver damage:
Experimental liver injury in rats caused by toxins such as carbon tetrachloride (C), hemisaccharamine, and acetamide sulfide can be prevented by pre-injecting a certain dose of PQQ and its derivatives intraperitoneally. PQQ can reduce the generation of ROS caused by hepatotoxic substances, significantly reduce the levels of serum bilirubin alanine aminotransferase (glutaic pyruvic transainese, GPT) and dehydrogenase, block liver cell necrosis, and does not affect the conventional biochemical indicators of rats (such as blood sugar, blood and urine nitrogen, etc.).
Japanese W+NMN has dual biological functions of neuron nutrition and neuroprotection
It plays an important regulatory role in the growth, development, differentiation, regeneration and specific expression of biological functions of the middle bundle and peripheral neurons. Experiments show that in vitro, PQQ can stimulate LM cells and Schwann cells to produce NGF. nmn is science or IQ tax, nmn new news!
4. The degree of rejuvenation of human physiological indicators by W+NMN end tower in Japan
Japan W+NMN anti-flame effect:
Peroxynitrite, formed endogenously in the diffusion-limited reaction of NO and superoxide, is a strong oxidant associated with the pathophysiology of inflammation, such as ischemia-reperfusion injury, atherosclerosis, acute pneumonia, and sepsis. ERGO can inhibit amino acid oxidation mediated by peroxynitrite anion, such as tyrosine nitration, thus providing feasibility for the diagnosis and treatment of inflammation.
Japan's W+NMN enhances the cognition function of changing meals
PLAS plays an important role in the living body, and it is one of the main components of the cell membrane. There are reports that it can protect nerves, form myelin, stabilize the flow of cell membranes, store polyunsaturated fatty acids, and help conduct signals. In addition, studies have shown that Plas is largely absent in the brain and blood of patients with Alzheimer's disease, and oral administration of PLAs can improve cognitive function.
rejuvenate nerve cells
Neuron protrusion, nerve cell strengthening
Protect brain cells from oxidation
Prevent neuronal apoptosis
reduce neuroinflammation
Metabolic amyloid beta accumulation
Improve memory and learning
Women: Anti-aging by improving the function of rod cells after upgrading W+NMN in Japan
The dermal rod cells help produce substances such as collagen, but the dermal rod cells decline with age. Therefore, in the treatment in recent years, the anti-aging treatment is carried out by oral administration of fibroblasts of W+NMN. The dermis cells and fibroblasts exist in the dermis deep in the skin.
The doctor pointed out that because of its powerful functions of redifferentiation and immune regulation, NMN has the effect of rejuvenating the face, delaying the decline of organ and tube function, and improving the body's resistance.
Women: Cell belly-repairing factor derived from Japanese W+NMN upgrade, enhancing "multi-directional differentiation potential" belly-repairing power
Why can W+NMN technology solve aging skin problems? Because W+NMN is the real proof to solve skin quality problems from the root of cells. When people reach a certain age, to solve the skin quality problems caused by aging, they can no longer do superficial efforts, but need to go deep into the underlying cells of the skin to solve them.
W+NMN is to use the potential ability of NMN to transform into other cells in the body to repair various degenerative, necrotic, damaging, metabolic and degenerative lesions, and restore damaged or degenerated cells. The transformation of W+NMN cell belly repairing factor culture and differentiation is as follows
1) TGFBeta-1 Transformed growth factor β1
2) FGF-2 Basic Fibroblast Growth Factor
3) VEGF Vascular Endothelial Growth Factor
4) PDGF platelet-derived growth factor
5) HGF Hepatocyte Growth Factor
6) Collagen Type - 1 Collagen Type Ⅰ
W+NMN can be differentiated into various cells or tissue cells, and it can be transformed into tissue cells after tissue organelles are damaged.
Men: Japanese W+NMN research on preventing alcohol-induced liver damage
Stimulation of the SirT1/PGC-1α/mitochondrial biosynthesis pathway attenuates alcohol-induced liver injury; over time, excessive alcohol intake leads to disease, which usually does not cause many symptoms in the early stages but still produces severe liver damage. This alcohol-induced damage arises from three factors: inflammation, metabolic dysfunction and oxidative stress -- the buildup of compounds called reactive oxygen species that damage cells, proteins and DNA.
In this study, W+NMN was shown to protect against alcohol-induced liver damage. In the study, Atf3 activity increased approximately 40-fold in those who did not receive NMN compared to those who did not drink alcohol. Although it did not completely moderate Atf3 overexpression, NMN improved it significantly, as NMN injectors reduced this activity by about 5-fold.
The research team believes that NMN prevents the uncontrolled accumulation of scar tissue called fibrosis in the liver and also lessens the damaging effects of alcohol on the liver. For the average adult who drinks slightly above the recommended amount of alcohol, once more than two drinks, enhancing liver function with NMN supplementation may be a beneficial way to promote liver health.
The key substance to accelerate the metabolism of alcohol is NAD+. NAD+ is a substance that is inherent in the human body and will be slowly lost with the growth of physiological age. NMN is the direct precursor of coenzyme I (NAD+). Taking NMN before and after drinking alcohol can quickly increase the NAD+ content in the body in about 15-30 minutes. NAD+ is specially used to cut hydrogen ions, and take away a few electrons by the way. Two-step interception, alcohol becomes the fuel of life, even if the amount of alcohol is doubled, there will be no headaches.
Men: Upgraded Japanese W+NMN black gold version, improving sleep quality and physical function of the elderly
Through the schematic diagram of biological clock, energy and metabolic pathways above, we can see the principle of NMN improving diet and sleep. Supplementing NMN can increase the level of NAD+ in the body, and NAD+ has a lot to do with the biological clock. The interactions suggest that NAD+ meabolism is regulated by the circadian clock, which in turn has an effect on the circadian clock. In short: NAD+ can regulate the biological clock through SIRT1, which can help treat sleep disturbance caused by circadian rhythm reversal or cause.
Conclusion: Both the academic mainstream and everyday consumers are very optimistic about the prospect of NMN in the field of anti-aging. At present, many multinational giants in the world have made great progress in the field of NMN research. NMN can fundamentally slow down aging and help the human body stay young. ~ MM ~ nmn is science or IQ tax, nmn new news!