Why nmn can anti-aging, NMN anti-aging effect, a comprehensive analysis! Why nmn can resist aging, NMN anti aging effect, comprehensive analysis!
Aging is a natural law, but eternal youth and youth have always been pursued by people, and everyone is looking forward to slow aging. The development trend of science has brought us many unexpected surprises. NMN is recognized as a substance that can reverse the aging of mammals in recent years. It has the effect of anti-aging and freezing age, and has attracted attention from all walks of life.
Scientific Analysis of Japan W+NMN25000 Platinum Edition: Why NMN Can Anti-aging, NMN Anti-aging Effect
Japan W+NMN25000 Scientific Analysis: Why can nmn anti-aging, anti-aging effect of NMN
If you want to look youthful, you have to nourish from the inside out. Only when we really understand the causes of human aging, can we find the breakthrough point and realize the beautiful wish of eternal youth.
Why do we age? Imagine that our human body is like a huge machine, and the cells that make up our human body are like parts of the machine. It is the natural operation of the cells that allows our life to continue, but the "machine" will always have some wear and tear during the operation process. This is also the reason why our body keeps aging.
Among them, one of the key factors is NAD+. NAD+ is an organic compound that can help cells use oxygen for energy metabolism, and can also help some enzymes in cells to react. It is a key factor for maintaining a young and healthy human body. However, NAD+ will decrease sharply with age, and the consumption is greater than the output. Generally, when the human body reaches the age of 40, the amount of NAD+ drops to half of the peak value. From the outside, it means that people have aging phenomena such as facial looseness, stains, and wrinkles.
It is precisely because nmn is the precursor of NAD+, which can increase its number in cells. Therefore, the Japanese W+NMN 25000 Platinum Edition has a direct and fundamental anti-aging effect. W+NMN25000 stimulates 7 longevity proteins (sirt1- sirt7) to increase NAD+ levels, repair DNA, stimulate immune cells, and maintain mitochondrial health.
As the precursor of NAD+, nmn can increase its number in cells. Therefore, Japanese W+NMN25000 has a direct and fundamental anti-aging effect. W+NMN25000 stimulates seven longevity proteins (sirt1-sirt7) to improve the level of NAD+, repair DNA, and stimulate immune cells. Maintain mitochondrial health.
The ingredients of the upgraded W+NMN Platinum Edition:
Basidiomycetes-X：
Scientists from many research institutions such as Santa Mariana Medical University in Japan have found that Basidiomycetes-X is rich in anti-aging substances, has a significant incremental effect and an increase in phagocytic activity, improves and inhibits daily life syndromes (cardiovascular and cerebrovascular diseases, hypertension, liver disease, diabetes, kidney disease, obesity, etc.), has a strong antioxidant capacity, and increases immunity. Plasma levels of insulin resistance and adiponectin and triglycerides were significantly improved.
PQQ
PQQ activates mitochondria, maintains brain function and prevents brain aging diseases. It has anti-inflammatory effects and can help resist various diseases. It also activates and supports many other protective mechanisms related to lifespan extension and health.
EGCG
EGCG has various biological activities such as antibacterial, anti-inflammation, and prevention of cardiovascular and cerebrovascular diseases. It can prevent and treat cardiovascular diseases and its effects, scavenge free radicals, and protect the kidney and liver.
Significantly enhance cell activity, promote oocyte maturation, embryonic development, and promote hair growth.
Life Ceramics
Anti-oxidant, anti-aging, vital water promotes energy metabolism, restores cells and rejuvenates.
Lifeceramics not only removes active oxygen, but also helps promote the recycling of original antioxidant substances in the human body, improving vitality and immunity.
In fact, some scientific researchers and women who are committed to fighting against aging have taken NMN in order to try to slow down their own aging phenomenon through advanced scientific and technological means. In the few months after taking Japanese W+NMN25000, they obviously felt that not only the quality of sleep is getting better and better, but also the skin is shiny. These all show that taking NMN can achieve a significant effect of anti-aging and anti-aging!
The effect of W+NMN anti-aging and anti-aging: the degree of rejuvenation of human physiological indicators by eliminating senescent cells (zombie cells)
The latest aging biology textbook in 2019 summarizes decades of aging research and attributes the mechanism of aging to two major problems: oxidative self-oil damage and a decline in NAD+ levels.
A review was published, which introduced that W+NMN reduces senescent cells (zombie cells) by 18% after 12 days of use, and that W+NMN can reduce senescent cells (zombie cells) in the human body by 37% for one year.
W+NMN reduced senescent cells (zombie cells) by 18 percent after 12 days of use, and W+NMN reduced senescent cells (zombie cells) in human body by 37 percent after one year.
The age-defying difference between W+NMN 25000 Platinum Edition and ordinary NMN : The cell repair enhances the repairing power of the skin
With the increasing maturity of W+NMN technology, research on new-generation technologies such as exosomes and cytokines has been derived. Cytokines are polypeptide substances secreted during the growth of W+NMN. Common members include EGF, bFGF, TGF-β, NGF, VEGF, etc., which promote fibroblast metabolism, collagen regeneration and tissue repair.
With the increasing maturity of W+NMN technology, a new generation of exosomes, cell factor and other technologies have been developed. Fine cell factor is W + NMN foster growth of polypeptide secreted substances, common members including EGF, bFGF, TGF - beta, NGF plays, such as VEGF, thin cell metabolism and promote fibroblasts collagen 苼 again and fix the function of the complex.
In human skin, there are many collagens that connect cells and support the skin structure, which is the key to making the skin plump, delicate and smooth. W+NMN wakes up and repairs damaged skin cells, improves cell rejuvenation ability; enhances the self-regulation ability of the endocrine system, repairs the skin's water retention performance, reduces the appearance of wrinkles, and keeps the skin tender and smooth; at the same time improves cell circulation
W+NMN wake up and repair damaged skin cells, improve the ability of cells to regain life, Enhance the internal secretion system self-regulation ability, repair the skin water retention performance, so that the skin to reduce the generation of wrinkles, keep delicate and smooth; At the same time, the fine cell circulation is improved
After W+NMN acts on the face, the facial skin secretes collagen, hyaluronic acid, elastic fibers and other substances, making the skin firm, white and lustrous, diluting pigmentation, and repairing sensitive skin damage caused by air pollution and ultraviolet radiation.
W+NMN is the fundamental cell for rejuvenation and restoration of youthful appearance, providing a sufficient source for cell renewal and rejuvenation of the skin system. The cell metabolism of Xinsheng is strong, it can discharge waste in time, prevent the deposition of skin pigment, inhibit and reduce the formation of spots; the young cells differentiated by Xinsheng have better water retention, which is enough to restore the delicate and smooth aging skin; at the same time, synthesize a large amount of collagen and elastin, restore skin elasticity, reduce wrinkles, and fundamentally improve and repair the quality of the skin system. Why nmn can anti-aging, NMN anti-aging effect, a comprehensive analysis!
When it comes to NMN, everyone already knows
But when it comes to the platinum version of W+NMN 25000 , everyone only knows that it is good.
What's so good about it? Many people don't necessarily know (the difference between W+NMN black gold version and NMN)
Today we will take stock of the new standard of the Japanese W+NMN 25000 Platinum Edition :
1. High absorption and utilization rate
From level 1 to level 15 purification, the human affinity and utilization rate reached the peak, realizing a major leap from a single component NMN to a compound component type W+NMN, greatly improving the conversion efficiency of NAD+, and also changing the disadvantages of low absorption and single function of traditional NMN products. W+NMN has the technology to clean up the obstacles that hinder the release of NMN in the body.
After supplementation, it can stimulate the biosynthesis of mitochondria by stimulating the PGC-1α, TFAM pathway, and cAMP response element binding protein pathway, and can strengthen and restore the function of mitochondria and repair abdominal damage, and finally express a variety of beneficial effects on the body;
2. High energy efficiency and excellent resilience
Japan's W+NMN25000 Platinum Edition super high-quality compound ingredients work together to maintain a high balance of ingredients.
PQQ stimulates mitochondria, maintains brain function and prevents brain aging diseases, strengthens neurons and brain nerve nutrition, improves peroxidative damage in biological organisms, has a wide range of biological activities such as catalyzing redox reactions, promoting mitochondrial generation, regulating energy metabolism, and regulating cell signaling pathways. The United States and the European Union have listed it as a high-safety dietary supplement.
As a rare natural antioxidant, ERGO has strong stability and is an important physiologically active substance in the body. It plays a role in removing bacilli, regulating intracellular redox reactions, and participating in the regulation of intracellular energy.
PLAS plays an important role in the living body, and it is one of the main components of the cell membrane. It has been reported that it can protect nerves, form myelin sheath, stabilize the flow of cell membranes, store polyunsaturated fatty acids, help conduct signals, etc. It is found that it can significantly increase the survival rate of PC12 cells and restore the cell shape;
3. High standard execution
Japan is the only country in the world that listed NMN as a legal drug and food raw material, and took the lead in conducting clinical trials; Japanese officials have perfect requirements and strict supervision on the production specifications, safety, purity requirements, and testing methods of NMN raw materials and products.
GRAS certified raw materials
GMP pharmaceutical grade production
Refined component analysis
SGS strict testing
4. Laboratory-grade raw materials, Platinum version 25000 more reliable double + bio-enzymatic extraction
The most active form of nicotinamide mononucleotide, W+NMN capsules are high-quality NMN25000, using laboratory-grade raw materials for production, and obtaining high-quality NMN raw materials through continuous optimization of the production process. Using sophisticated detection methods to ensure high density and high content, and to carry out clinical experiments to verify safety and efficacy.
Using cutting-edge technology: double + enzymatic evolution technology, full enzymatic preparation, W + NMN25000 black gold version has a purity of more than 99%, and has better biological activity.
5. Five-level enhanced boost: Four protection technologies enable the complete release of NMN in the body,
1) Super boost boost: converted into NAD+;
2) Level-enhancing boost: promote the consumption of the enzyme PARP;
3) Level-strengthening boost: Regulate Sirtuins fine bud longevity protein;
4) Level-up boost: release the NMN essential wake-up agent W+NMN (telomere tower) to wake up the dormant NMN in the body. Studies have shown that Slc12a8 in the small intestine plays an important role in transporting NMN from the intestine to circulation, affecting NAD+ levels in the small intestine and systemic NMN supply in vivo.
5) Level-strengthening boost: four core regulatory factors, and are directly related to mitochondrial production and function improvement, strengthen and restore mitochondrial function and repair abdominal damage; why nmn can resist aging, NMN's anti-aging and anti-aging effect, a comprehensive analysis!
Multinational authoritative clinical verification report released:
The difference between W+NMN Platinum Edition and ordinary NMN, after W+NMN Platinum ,
1. The degree of rejuvenation of human physiological indicators by W+NMN
The benefits of W+NMN on the brain:
Current research focuses on the ability of PQQ to protect memory and cognition in aged animals and humans in W+NMN. Here are some of the effects noted in animal studies involving PQQ: Blocks the formation of several compounds that are harmful to brain cells. Protects against autooxidation of the D-1 gene, an early step in the pathogenesis of Parkinson's disease. Protects brain cells from oxidative damage. Reverses cognitive impairment caused by chronic oxidative stress and improves performance on memory tests in animal models of diet. Protects the brain from the neurotoxicity of glutamate, mercury, amine oxide (a potent neurotoxin used by scientists to induce Parkinson's disease in laboratory animals), and other potent toxins. Prevents the development of a protein associated with Parkinson's disease. Protects nerve cells from damage from the beta-amyloid protein associated with Alzheimer's disease.
W+NMN prolongs service life:
The way PQQ promotes mitochondrial growth has been shown to have extraordinary additional efficacy effects. Supplementation with PQQ turns on gene expression pathways regulated by PGC-1a, a well-known stimulator of mitochondrial biogenesis. This appears to be done by activating SIRT1, a sirtuin regulator protein. Many recent studies have shown that sirtuins help regulate cellular health, prevent disease and age-related loss of function, and play a role in extending lifespan.
In other words, PQQ not only triggers mitochondrial biogenesis, it also stimulates and supports many other protective mechanisms associated with lifespan extension and health.
In addition to all these effects, as an antioxidant, PQQ also removes harmful free radicals. Many other nutrients can only quell oxidative stress for a short period of time. For example, vitamin C can only participate in the beneficial redox cycle of about four cycles. In comparison, one PQQ molecule can go through a staggering 20,000 cycles!
Thanks to all these abilities, PQQ has proven that it can prolong life. The worm (C. elegans) is an animal model commonly used to study longevity because of its relatively short lifespan. Two different research groups used the model to assess the life-extending effects of PQQ.
In both studies, supplementation with PQQ resulted in a significant increase in the average lifespan of the treatment animals. In fact, the studies had nearly identical results, with one study increasing life expectancy by an average of 30 percent, while the other increased lifespan by 31 percent.
Dr. Ames is a widely respected professor emeritus of biochemistry at UC Berkeley and has also worked at the National Institutes of Health. Dr. Ames writes frequently about nutrients that extend life and improve diet health. Dr. Ames included PQQ on his short list of "longevity vitamins" based on its ability to stimulate mitochondrial biogenesis.
The activity of brain vascular cells after W+NMN modified diet oxidative stress
In experiments, the team found that NMN protected mouse endothelial cells grown in laboratory dishes treated with the oxidative stress-inducing molecule hydrogen peroxide. Treatment with hydrogen peroxide for 12, 24 and 48 hours resulted in a progressive decrease in cell viability. Even more, additionally increasing the supplemental concentration of NMN (300 to 500 M) promoted better cell proliferation rates. These results suggest that NMN can reverse the deleterious effects of oxidative stress on brain endothelial cells, which are caused by metabolic disturbances. Why NMN can anti-aging, NMN anti-aging effect, a comprehensive analysis!
W+NMN enhances mitochondrial health after oxidative stress
To find out whether the NMN-induced increase in cell survival came from improved dietary mitochondrial health, the scientists examined the structural integrity of mitochondrial membranes. After the harmful hydrogen peroxide treatment, they found that the mitochondrial membrane was more permeable, indicating reduced structural integrity. Addition of NMN to the hydrogen peroxide treatment restored mitochondrial membrane potential, suggesting restoration of mitochondrial health. These results suggest that NMN increases cell survival under oxidative stress by improving the integrity and health of mitochondrial membranes.
NMN protects against oxidative stress-induced mitochondrial damage. The ratio of red to green fluorescence indicates mitochondrial membrane permeability—the ability of ions to pass through the mitochondrial membrane. Higher ratios represent lower membrane permeability, indicating greater structural integrity. In this experiment, NMN restored the structural integrity of mitochondrial membranes after treating cells with hydrogen peroxide, a molecule that triggers oxidative stress.
Effects of W+NMN on cellular pathways
To clarify how NMN rescues cells from the toxic effects of oxidative stress, the researchers examined levels of the proteins NF-ĸB and NAMPT, as their levels fluctuate with inflammation and disease. NF-ĸB is a protein complex that coordinates the immune response and the cellular response to oxidative stress, while NAMPT is the enzyme in cells that synthesizes NMN from nicotinamide. Luo and colleagues found that NMN increased NAMPT levels and decreased NF-ĸB levels after hydrogen peroxide treatment. Changes in NAMPT and NF-ĸB levels indicated that NMN treatment modified NAD+ biosynthesis and reduced inflammation, respectively. This insight could help researchers understand the cellular mechanisms by which NMNs function, leading to better therapeutics targeting these cellular pathways.
NMN treatment of mouse brain endothelial cells leads to reversal of oxidative stress-induced NAMPT and NF-KB effects. Treatment with hydrogen peroxide, which induces oxidative stress, resulted in decreased NAMPT levels, whereas NMN reversed these effects. Hydrogen peroxide treatment promoted a significant increase in NF-KB levels, whereas addition of NMN reversed this effect.
Taken together, our results suggest that NMN has the ability to protect H2O2-bEnd.3 cells from apoptosis by regulating NAMPTase and NF-ĸB p65 signaling pathways,"
2. The degree of rejuvenation of human physiological indicators by W+NMN
Eliminate senescent cells (zombie cells)
The most well-known benefit of W+NMN is its effect on promoting longevity. Energy production and mitochondrial function decline with age, due in large part to the parallel decline of NAD in various cells and organs in the body.
Senescent cells are eventually lodged into cellular senescence, which means cells stop dividing and losing function: Senescence plays an important role in the process of aging and disease. The effects of cellular senescence can be mitigated by increasing NAD levels with supplementation of W+NMN.
Since NMN is the main precursor of NAD, supplementing with W+NMN is a beneficial way to reduce the cellular and mitochondrial decline and dysfunction that occurs with age.
3. The degree of rejuvenation of human physiological indicators by W+NMN
W+NMN protects the heart from oxidative damage:
The protective effect of PQQ on the heart is related to the ability of empathy to remove from the oil base. PQQ can eliminate reactive oxygen species (ROS) produced by hypoxia-reperfusion, and significantly reduce the release of dehydrogenase in the heart. Under the catalysis of flavin reductase, its catalytic product can also reduce the peroxidation state of hemoglobin, and eliminate the damage to the myocardium caused by hypoxia-reperfusion. Studies have shown that the use of PQQ to protect the heart of ischemia-reperfusion mice significantly reduced the size of myocardial infarction, enhanced left ventricular pressure and left ventricular diastolic pressure rise and fall rate, reduced ventricular fibrillation, and reduced the level of malondialdehyde in myocardial tissue. PQQ can also inhibit the generation of ROS induced by hydrogen peroxide in rat cardiomyocytes and the reduction of mitochondrial membrane potential, thereby reducing oxidative stress, inhibiting the inactivation of mitochondrial function, and protecting rat cardiomyocytes.
W+NMN prevents liver damage:
Experimental liver injury in rats caused by toxins such as carbon tetrachloride (C), hemisaccharamine, and acetamide sulfide can be prevented by pre-injecting a certain dose of PQQ and its derivatives intraperitoneally. PQQ can reduce the generation of ROS caused by hepatotoxic substances, significantly reduce the levels of serum bilirubin alanine aminotransferase (glutaic pyruvic transainese, GPT) and dehydrogenase, block liver cell necrosis, and does not affect the conventional biochemical indicators of rats (such as blood sugar, blood and urine nitrogen, etc.).
W+NMN has dual biological functions of neuron nutrition and neuroprotection
It plays an important regulatory role in the growth, development, differentiation, regeneration and specific expression of biological functions of the middle bundle and peripheral neurons. Experiments have shown that in vitro, PQQ can stimulate LM cells and Schwann cells to produce NGF. Why nmn can resist aging, and the anti-aging effect of NMN, a comprehensive analysis!
4. The degree of rejuvenation of human physiological indicators by W+NMN
1. W+NMN anti-burning effect:
Peroxynitrite, formed endogenously in the diffusion-limited reaction of NO and superoxide, is a strong oxidant associated with the pathophysiology of inflammation, such as ischemia-reperfusion injury, atherosclerosis, acute pneumonia, and sepsis. ERGO can inhibit amino acid oxidation mediated by peroxynitrite anion, such as tyrosine nitration, thus providing feasibility for the diagnosis and treatment of inflammation.
2. W+NMN enhances the cognition function of changing meals
PLAS plays an important role in the living body, and it is one of the main components of the cell membrane. There are reports that it can protect nerves, form myelin, stabilize the flow of cell membranes, store polyunsaturated fatty acids, and help conduct signals. In addition, studies have shown that Plas is largely absent in the brain and blood of patients with Alzheimer's disease, and oral administration of PLAs can improve cognitive function.
rejuvenate nerve cells
Neuron protrusion, nerve cell strengthening
Protect brain cells from oxidation
Prevent neuronal apoptosis
reduce neuroinflammation
Metabolic amyloid beta accumulation
Improve memory and learning
3. Women: W+NMN aging oocytes have a protective effect
In May 2019, a study officially published in "Ienatu" found that aging affects the quality of oocytes by reducing NAD+ levels, which eventually leads to female physiological and fertility disorders. In a strict sense, aging is directly related to female physiology.
W+NMN, the NAD+ synthesis mediated by it has a protective effect on aging oocytes. It was found that the longer the mice ingested W+NMN, the more significant the increase in the blastocyst formation rate of oocytes and the development of the inner cell mass of the blastocyst. These two indicators are important factors in predicting the final pregnancy success rate, and their improvement indirectly indicates the improvement of fertility.
The current experiments at the cell level have shown that W+NMN intake (2g/L) can significantly improve the quality of oocytes in aged mice, thereby restoring fertility. With this conclusion in mind, the research set out to test whether W+NMN could indeed restore fertility in aged female mice at a "clinical" level.
The data shows that the pregnancy rate, live birth rate, and litter size of the 0.5g/L W+NMN intake group have all been greatly improved.
4. Women: W+NMN and dietary changes for women's body functions
As we grow older, the reduction of NAD+ levels leads to a decline in the ability of DNA to repair the belly, and the accumulation of DNA damage drives the aging process. NAD+ participates in cellular respiration in cells and promotes energy metabolism (such as oxidation of glucose, fat, and amino acids). NAD+ is not only a coenzyme for hundreds of redox reactions in human cells, but also serves as a substrate to participate in the regulation of various physiological functions such as cell survival, apoptosis, DNA repair, immune response, and circadian rhythm.
Studies have found that the decline in NAD+ levels will lead to abnormal communication between the nucleus and mitochondria, resulting in reduced DNA repair ability, DNA damage accumulation, and aging. As the precursor of NAD+, W+NMN synthesizes NAD+ through the NAD+ salvage synthesis pathway in cells. Supplementing W+NMN can increase the body's NAD+ level, which is greatly reduced due to aging and unhealthy conditions, and has great potential for delaying aging, preventing and treating various diseases.
5. Men: The upgraded W+NMN black gold version enhances the muscle performance of men
A clinical study in older men showed that taking NMN increased blood NAD+ levels and improved various markers of muscle strength and performance.
NMN increases blood NAD+ and NAD+ metabolite levels in men over 65 years of age.
Supplementation with 250 mg of NMN for 12 weeks enhanced muscle function and mobility.
To find out whether these NMN-induced increases in NAD+ levels could improve physical function, Yamauchi and colleagues tested muscle strength and performance. They found that NMN significantly improved several measures of muscle strength and performance: walking speed, grip strength, and the number of times the participants could get up from a chair in 30 seconds. Their results showed that oral NMN supplementation for 12 weeks improved muscle strength and performance in healthy older men.
6. Men: The upgraded W+NMN black gold version can improve the sleep quality and physical function of the elderly
Through the schematic diagram of biological clock, energy and metabolic pathways above, we can see the principle of NMN improving diet and sleep. Supplementing NMN can increase the level of NAD+ in the body, and NAD+ has a lot to do with the biological clock
Anti-aging and eternal youth have always been an enduring topic, but how to correctly anti-aging requires scientific methods. Taking NMN is one of the most useful methods at present. The anti-aging effect of NMN is a major discovery in the field of biological sciences. It is the secret of our ability to resist aging and the key to delaying the pace of time! ~ MM ~ Why NMN can resist aging, NMN's anti-aging effect, a comprehensive analysis!