In the past few decades, cerebroside sulfate is related to many physiological processes, and people have recently renewed interest in their role in diseases. In the brain and spinal cord, cerebroside sulfate has different fatty acyl chains, including saturated, unsaturated and 2-hydroxy fatty acids, the composition of which is essential to affect its function.
Let's unlock the biological significance of cerebroside sulfate.
1. Demyelinating disease
Nervous system diseases in which demyelination is the main or initial pathology and the axonal, cell body, and glial damage are relatively mild. Can occur in the central nervous system or peripheral nervous system.
2. Platelet aggregation
Cerebroside sulfate interacts with a variety of cell adhesion molecules, such as laminin, thrombospondin, hemophilia factor and selectin. Recently, they were identified as the main ligands of P-selectin in platelet adhesion and aggregation, which is necessary for the formation of stable platelet aggregation. It was found that platelets expressing cerebroside sulfate adhered to P-selectin, while platelets expressing P-selectin adhered to cerebroside sulfate. When the presence of cerebroside sulfate sulfate is masked by the formation of cerebroside sulfate micelles or the introduction of recombinant malaria cyclosporin protein bound to cerebroside sulfate, adhesion is inhibited. The cerebroside sulfate/P-selectin interaction may play an important role in hemostasis and thrombosis.
3. Leukotriene synthesis
In adherent human polymorphonuclear leukocytes, cerebroside sulfate has been found to inhibit the synthesis of leukotrienes by directly inhibiting 5-lipoxygenase and preventing its transport to the nuclear membrane. The mechanism of this inhibition may be due to the redistribution of cholesterol caused by cerebroside sulfate, thereby increasing its abundance in the tail foot.
Four, ovarian tumors
It is well known that cancer cells have abnormally high levels of glycolipids. It has been confirmed that the content of cerebroside sulfate is increased in the ovarian tissue of patients with advanced ovarian tumors. Elevated levels of cerebroside sulfate in these cells may play a role in the pathogenesis of ovarian cancer. These elevated levels of cerebroside sulfate can be used as biomarkers to predict the presence of advanced ovarian cancer, even if the patient seems to be in the early stages of the disease in some cases.
5. Research tools related to cerebroside sulfate
1.1049-50 Sulfide
Sulfapeptide is a sulfolipid mainly found in the central nervous system and is a myelin-specific sphingomyelin. Glucosinolate deficiency in white matter and gray matter is related to Alzheimer's disease and other types of dementia. Apolipoprotein E plays an important regulatory role in the metabolism of sulfamate. Anti-sulfamate antibodies are produced in the cerebrospinal fluid, leading to a deficiency of sulfamate, which may be the cause of myelin degeneration, leading to multiple sclerosis. Metachromatic leukodystrophy is a genetic disease characterized by a deficiency of the lysosomal enzyme arylsulfatase a and subsequent accumulation of sulfamate in nerve and visceral tissues. Some people think that sulfate has an immunomodulatory effect in the pathogenesis of tuberculosis.
2.1904-1 Hemolytic sulfate (NH4 + salt)
Hemolysin sulfamate is an ideal choice for the preparation of clear and labeled sulfamate, and it is ideal for enzyme and metabolism research. Sulfapeptide is a sulfolipid mainly found in the central nervous system and is a myelin-specific sphingomyelin. Glucosinolate deficiency in white matter and gray matter is related to Alzheimer's disease and other types of dementia. Apolipoprotein E plays an important regulatory role in the metabolism of sulfamate. Anti-sulfamate antibodies are produced in the cerebrospinal fluid, leading to a deficiency of sulfamate, which may be the cause of myelin degeneration, leading to multiple sclerosis. Metachromatic leukodystrophy is a genetic disease characterized by a deficiency of the lysosomal enzyme arylsulfatase a and subsequent accumulation of sulfamate in nerve and visceral tissues. Some people think that sulfate has an immunomodulatory effect in the pathogenesis of tuberculosis.
3.2076-1 N-acetyl sulfate
It is a well-defined sulfonamide peptide containing an acetyl group acylated to sphingosine, and is an ideal internal standard. Sulfonate is a sulfoxide mainly found in the central nervous system and is a myelin-specific sphingolipid. Glucosinolate deficiency in white matter and gray matter is related to Alzheimer's disease and other types of dementia. Apolipoprotein E plays an important regulatory role in the metabolism of sulfates. Anti-thiocyanate antibodies are produced in the cerebrospinal fluid, leading to a lack of sulfuric acid, which may be one of the reasons for myelin degeneration, leading to multiple sclerosis and other demyelinating diseases. Metachromatic leukodystrophy is a genetic disease characterized by a deficiency of the lysosomal enzyme arylsulfatase a, followed by accumulation of sulfonamide peptides in nerve and visceral tissues. The immunomodulatory effect of sulfa peptides has been proposed to reduce the in vitro production of pro-inflammatory cytokines in the pathogenesis of diabetes. Thiocyanate also regulates the differentiation of oligodendrocytes. The myelin sheath of the central nervous system (CNS) has a strong inhibitory effect on the growth of axons. The sulfate in the myelin sheath of the central nervous system has been identified as the main myelin-related axon growth inhibitor. In some cases, low serum sulfate levels are associated with an increased risk of cardiovascular disease. The sulfamate in myelin sheath, especially maleyl sulfamate, stimulates a unique population of CD1d-restricted natural killer T cells, which makes these sulfamate salts useful for designing myelin sugars in autoimmune diseases of the central nervous system Lipid-responsive T cell therapy is of great significance
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