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The pathogenesis of stroke
Ischemic Stroke Recognition and treatment of pathological mechanism of the new strategy
Dependence on brain blood flow
- When the cerebral blood flow was slightly lower than 50ml / 100g / min, still maintaining a substantially blood supply through cerebral vasodilation.
- When the blood supply to further reduce, when the process is divided into two phases cerebral hypoxic-ischemic pathology evolution, disorders in synaptic transmission and membrane pump failure.
The entire Wikipedia definition of the sodium-potassium pump and pictures.
Sodium potassium pump (also referred to as a sodium-potassium -ATPase, Na + / K ± ATPase), is an enzyme (EC 3.6.3.9) located on a cell membrane (or, more precisely that the transmembrane ion cassette enzyme ATP)
Sodium-potassium pump may extracellular relatively low concentration of potassium ion cell feed cells, the cells and the extracellular relatively low concentrations of sodium ions out cells. Via the sodium is radioactive, potassium calibration, can be found in a sodium, potassium will go through this channel, the sodium, potassium ion concentration on both sides of the membrane are also interdependent, shows the sodium and potassium ions can be through the carrier transport. Known sodium-potassium pump consumes ATP, and sodium ions can be fed three cells while the cell feed two potassium ions.
- When the cerebral blood flow is less than 20ml / 100g / min, oxidative metabolism of brain cells is inhibited, the electrical activity (spontaneous and induced) between neurons stop formed ischemic penumbra.
Modern medical research shows that around infarction will generally form a "penumbra." Cerebral ischemic penumbra was first proposed by experts and professors of neurology Lang Hongzhi. "Penumbra" of memory in a large number of brain cells in a dormant or semi-dormant state, these cells can only maintain their complete form, due to the lack of energy supply, unable to exercise original normal function.
- When the cerebral blood flow is less than 10 or 8ml / 100g / min, ATP synthesis terminates, an ion pump failure, brain cell necrosis.
Pathophysiology of ischemic damage
