Shandong discussion with the students to a teacher before graduating, he asked what is genomics? While engaged in biological information, but he did not give a specific explanation. Recent medical cell biology book in the first chapter I have related description, so to sum up.
Now the group studies, the narrow sense refers to the personal understanding of genomics and proteomics. Here, the term group, refers to a relatively complete genetic material, including the sum of the DNA between the genes and gene, i.e. genome, or all of the proteins expressed by the genome.
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The end of July early August in the group, many students talk about the content of a pile of books on the content and the study of. Bo Bo three often mention two epigenetic, i.e., DNA sequence variation and the study did not change the function of the gene can be inherited. There are many epigenetic study mentioned in the book.
DNA methylation: the role of DNA methyltransferase, in genomic CpG cytosines 5 'carbon position dinucleotide covalently binding a methyl group.
Histone code (protein acetylation, methylation, phosphorylation, polyadenylation, ubiquitination, glycosylation, carbonylation): wherein acetylation is introduced into the organic molecule of nitrogen, oxygen, carbon atoms acetyl CH3CO- reaction; histone methylation site is a lysine and arginine, lysine may each be mono-, di-, tri- methylated arginine is only one, dimethyl glycosylation; phosphorylation is the phosphate groups on an intermediate metabolite or added protein; polyadenylation refers to a covalent link polyadenylated messenger RNA (mRNA) molecules, synthesized protein biosynthesis process, which is part of the preparation for generating mature mRNA translation mode; refers ubiquitination ubiquitin (a low molecular weight protein) molecules in the range of action of special enzymes, the protein in the cell classification, to choose the target protein molecules, and specific modification of the target protein; glycosylation enzyme is under the control of, the additional protein or lipid sugars process, starting in the endoplasmic reticulum, Golgi ends; carbonyl the preparation of the aldehyde, ketone carbonyl An important method of composition.
As for how to use machine learning methods to predict, certainly first of all is to have finished cleaning the data, that is, standard data sets, this process must first establish a good biological model, or existing biological models to understand the condemnation to the corresponding data put into a.
Genomic imprinting
The apparent genomics