Modification of triethylene glycol polyglutamate (P(EG3Glu)) with different secondary structures (L-, D-, or DL-) to gold nanoparticles in different directions (C-terminal or N-terminal) Particle surface, and study its endocytosis behavior. The results showed that gold nanoparticles modified helical polypeptides anchored from the C-terminus ((LC)-AuNPs) showed higher zeta potential and more endocytosis (about 2.0-5.5 times) than other modification methods. ). In addition, the difference in endocytosis caused by this orientation has also been further confirmed in gold nanorods (AuNR) and polypeptide amphiphilic helix polymers loaded with doxorubicin drugs. Analysis suggests that the molecular mechanism of this phenomenon is most likely to come from the rigidity of the secondary structure of the polypeptide spiral and its spiral dipole moment. When a large number of such polypeptides are arranged in parallel on the surface of the nanoparticle in a certain orientation, it brings about the macroscopic difference of the surface properties of the nanoparticle, such as surface hardness and zeta potential, and further affects its endocytosis. This hypothesis was further verified by the dissipative particle dynamics (DPD) simulation. This research provides a simple and convenient method for regulating the endocytosis of nanoparticle cells, prompting people to pay attention to such subtle structural changes when designing biomedical nanoparticles, especially those based on polypeptide polymers. The recent differences in nature provide a new way for people to better understand the nanoparticle-cell interaction.
We can provide gold nanoclusters/gold nanospheres/gold nanocages/gold nanoshells/gold nanostars/gold nano triangles/gold nanowires/gold nanospheres/gold nanorods and other gold products. We can modify the amino aldehyde hydroxy carboxy maleimide on these gold materials to functionalize these gold nano products. The related customization list is as follows:
Deoxyglucose and polyethylene glycol modified magnetic nanoparticles
Aminosilane functionalized ferroferric oxide magnetic nanoparticles (A-SMNPs)
mesoporous silica-coated ferroferric oxide nanocomposite particles
SiO2/3-aminopropyl trioxide Ethoxysilane (APTES) modified magnetic nanoparticles
, magnetic Fe3O4/SiO2 composite nanoparticles modified by amino group,
nimotuzumab
-coated ferroferric oxide nanoparticles, single-coated phospholipid-PEG magnetic iron oxide nanoparticles with
carboxyl group PEG-modified ferroferric oxide magnetic nanoparticles
Pectin-modified magnetic nanomaterials
Polyethyleneimine (PEI) modified ferroferric oxide (Fe 3O 4) nanoparticles (PEI-Fe 3O 4)
3-aminopropyl Trimethoxysilane (APTMS) Modified Magnetic Fe3O4 Nanoparticles
Ethyl Orthosilicate (TEOS) Modified Magnetic Fe3O4 Nanoparticles
Tetraethoxysilane Modified Ferroferric Oxide Magnetic Nanoparticles
Functionalized Modified Tetraoxide three ferromagnetic particles
carboxyphenyl boronic acid-modified magnetic nanoparticles CPBA-MNPs
tetraethoxysilane / γ- aminopropyltriethoxysilane silane-modified magnetic iron oxide particles four
aminosilane magnetic particles of AMPs
of Fe_3O_4 coated magnetic nanoparticles Carbon nanotube complex
Dopamine modified ferroferric oxide magnetic nanoparticles
Zinc-doped superparamagnetic ferroferric oxide nanoparticles
PEI-coated dual-modal contrast agent ferroferric oxide-gadolinium hydroxide
magnetic nanoparticles immobilized amino groups Acylase
Chitosan Quaternary Ammonium Salt Modified Ferroferric Oxide Magnetic Nanoparticles
Polyethylene glycol modified resveratrol nanoliposomes encapsulated with
ferroferric
oxide . Organic acid modified magnetic nanoparticles. Alkane chain modified hydrophobic magnetic nanoparticles. Magnetic nanoparticles modified with
ADM and As2O3. ferroferric oxide magnetic nanoparticles (DMSA-Fe3O4 MNPs) ADM- As2O3 MNPs
rich amino polyamidoamine dendrimer (of PAMAM) modification of Fe3O4 magnetic nanoparticles
single amino acid modified Fe3O4 magnetic nano material (Fe3O4 @ AA)
amino acids (AA ) Modified Fe3O4 magnetic nanoparticles (Fe3O4 MNPs)
long-chain polyarginine (PA) modified Fe3O4 magnetic nanoparticles (Fe3O4 MNPs)
lysine modified Fe304 magnetic nanoparticles
wogonin-magnetic ferroferric oxide nanoparticles Wog -MNPs-Fe3O4
betaine modified ferroferric oxide nanoparticles
RGD polypeptide-targeted zinc-doped ferroferric oxide nanoparticles
carboxymethyl chitosan modified ferroferric oxide magnetic nanoparticles
modified with sulfhydryl polyethylene glycol The photo-magnetic composite nano-materials
molybdenum disulfide/carbon fiber composite absorber material modified ferroferric oxide nano-magnetic particles
Bovine serum albumin modified nano ferroferric oxide (Fe3O4) magnetic particle
protein (OPN) targeted ferroferric oxide ( Fe2O4) nanoparticles
Dithizone modified Fe2O4 nanoparticles
Dextran-coated Fe2O4 nanoparticles
Bifunctional nanoparticles Fe3O4 nanoparticles
Concanavalin A modified magnetic Fe3O4 Nanoparticles
Polymer poly(N isopropyl isoacryloyl) modified magnetic ferroferric oxide nanoparticles
Dextran co-modified superparamagnetic nanoparticles (SPION)
copper nanoparticles modified on magnetic ferroferric oxide nanoparticles
Mesoporous silica-coated positively charged gold
nanoparticles Polyethyleneimine/polyethylene glycol modified gold nanoparticles.
Gadolinium-gadolinium chelating agent DOTA-NHS-loaded dendrimer-encapsulated gold nanoparticles.
Cyclodextrin-modified dendrimers molecular gold nanoparticles encapsulated
pegylated dendrimer encapsulated gold nanoparticles
RGD peptide modified multifunctional dendrimer encapsulated gold nanoparticles
hyaluronic encapsulated gold nanoparticles
of chitosan wrapped nanogold
diatrizoate Acid/folic acid-modified multifunctional dendrimer-encapsulated gold nanoparticles Au DENPs
targeting liposome-encapsulated aqueous gold nanocomplexes
Chitosan-modified polyurethane and chitosan-encapsulated gold nanoparticles
modified with folic acid-modified multifunctional targeting Contrast agent magnetic iron oxide/gold nanoparticles
Folic acid modified polyamide-amine dendrimer gold nanoparticles with diatrizoic
acid, citrate-encapsulated gold
nanoparticles, gold nanoparticles functionalized molybdenum disulfide nanocomposite,
lysozyme functionalized Gold Nanoparticle Materials
Luminol and Derivatives Functionalized Gold Nanomaterials
DNA Functionalized Gold Nanoparticles
Peryleneimide Functionalized Gold/Silver Nanoparticles
Calixarene Functionalized Gold Nanoparticles
Lysine Modified Perylene Substrate Amine functionalized gold nanoparticles Functionalized gold nanoparticles coated with
multi-layer shells
Low algebraic PAMAM coated gold nanoparticles modified with lactobionic acid
Lipoic acid functionalized gold nanoparticles Dendritic
polyphenylene/gold composite nanoparticles
functionalized Pd@Au Nanoparticles
Antioxidant ligand functionalized gold nanocomposite
Functionalized diamond nanoparticle
Polypeptide-functionalized gold nanoparticles
PEG-functionalized PAMAM dendrimers encapsulated by
gold nanoparticles. Gold nanoparticles-modified thiophenol-functionalized graphene composites
. Multifunctional targeting contrast agent modified by folic acid. Magnetic iron oxide/gold composite nanoparticles
triplet pyridine derivatives β- diketone ligand rare earth complexes of gold nanoparticles coated
gold nanoparticles modified multi-walled carbon nanotubes (of MWCNTs)
polyfunctional surface-modified nanoparticles of metal
nanotube / polyaniline / gold nanoparticle composites
with Functional Nanoparticles/Graphene Oxide Nano Hybrid Materials Modified by Position Bonds
Bovine Serum Albumin Modified Gold Nanoparticles Gold
Nanoparticles Functionalized Reduction of Graphene Oxide (RGO) and Multi-Walled Carbon Nanotubes (MWCNTs)
Platinum-modified dendrites Gold nanocomposite
C18 bonded nano-gold modified silica particles
Graphene (GS)-chitosan (CS)-Nano-Au composite
nano-gold (Au) coated clenbuterol-bovine serum albumin (CLB-BSA)
zzj 2021.3.17