Light therapy is a method of selectively killing cancer cells through light therapy and light irradiation. PTT uses light absorbers to generate heat under near-infrared (NIR) laser irradiation, resulting in thermal ablation of cancer cells. PDT uses photosensitizers exposed to specific wavelengths of light to produce cytotoxic reactive oxygen species, such as singlet oxygen (1O2), which makes the substance toxic to specific cancer cells or diseased cells to achieve a therapeutic effect. In addition to using small molecule reagents as phototherapeutics for the above phototherapy, many nanomaterials, including gold nanostructured materials, silver nanoparticles, carbon nanotubes, magnetic nanoparticles, two-dimensional nanomaterials, quantum dots, porphyrins, metal organic Frameworks (MOFs), NIR dye-encapsulated nanoparticles and semiconducting polymer nanoparticles (SPNs) have been widely studied and applied to PTT and PDT.
Using cell membranes to modify the surface of nanoparticles is a new strategy to endow nanoparticles with excellent biological interface properties. It has attracted widespread attention in the field of nanomedicine, including drug delivery, imaging, detoxification, vaccination, phototherapy and other fields. Membrane camouflage nanoparticles are composed of synthetic nanoparticles and the outer layer of natural cell membranes. Synthetic nanoparticles can be inorganic/organic nanoparticles with different biological and therapeutic functions, while the natural cell membrane layer has the relevant functions of the source cell, including immunity Escape and long-term circulation in the body.
Summarize and compare the sources of natural cell membranes, the types of nanoparticle "nuclei" and coating methods; and discuss in turn the use of red blood cell membranes (RBC), cancer cell membranes, platelet membranes, macrophage membranes, stem cell membranes, fibroblast membranes and myeloid The advantages of nanoparticles that inhibit cell membrane camouflage; also discussed in detail the immune escape ability, prolonged circulation time in the blood, the targeting ability of homologous tumors, and the phototherapy effect of this bionic particle, and compared with uncoated natural cell membranes The original nanoparticles are compared. Finally, the potential challenges and prospects of developing cell membrane camouflage nanoparticles for phototherapy are described.
We can provide the following customized synthetic composite materials:
Oil-soluble Fe3O4
Water-soluble
Fe3O4 PEG modified
Fe3O4 Chitosan modified
Fe3O4 Dextran modified
Fe3O4 COOH modified Fe3O4
Silicon dioxide coated Fe3O4
amination /Carboxylated silica coated Fe3O4
Polypyrrole coated
Fe3O4 Core-shell Fe3O4@SiO2 nanoparticles
Core-shell Fe3O4@SiO2 nanoparticles (amino modification)
Polyethylene glycol coated Fe3O4 magnetic nanoparticles
modified with amino Ferroferric oxide magnetic nanoparticles-NH2-Fe3O4
amino functionalized polyethylene glycol coated Fe3O4 magnetic nanoparticles
carboxyl functionalized polyethylene glycol coated Fe3O4 magnetic nanoparticles
poly-L-lysine/PLL ) Wrapped Fe3O4 magnetic nanoparticles
Polymer-polyethyleneimine (PEI) wrapped Fe3O4 magnetic nanoparticles
Bovine serum albumin (BSA) wrapped Fe3O4 magnetic nanoparticles
Streptavidin (Streptavidin) wrapped Fe3O4 magnetic nanoparticles
Mesoporous dioxide Silicon coated superparamagnetic Fe3O4 nanoparticles
Mesoporous silica coated superparamagnetic Fe3O4 nanoparticles surface amino modified
PAA polyacrylic acid coated magnetic Fe3O4 nanoparticles
Fe3O4 magnetic nanoparticles modified by fluorocarbon chains Fe3O4 magnetic nanoparticles
modified by dextran
shell Glycan-coated Fe3O4 magnetic nanoparticles
Galactose-coated Fe3O4 magnetic nanoparticles
Fe3O4 magnetic nanoparticles coated with hyaluronic acid
Polystyrene coated Fe3O4 magnetic microspheres, particle size 100±50 nm
Amino-modified Fe3O4 magnetic nanoparticles
Carboxyl-modified Fe3O4 magnetic nanoparticles
Nano-Au (nano-Au) immobilized alpha-fetoprotein antibody (anti-AFP)
ionic liquid encapsulated nano-gold modification
Carbon encapsulated nano metal particles
Polymer liposome encapsulated nano-gold (LADL@Au NPs)
Mesoporous silica encapsulation He Nami gold positively charged
polyethyleneimine / gold nanoparticles modified with polyethylene glycol
dendrimer load gadolinium Gd chelators DOTA-NHS wrapped gold nanoparticles
cyclodextrin modified dendrimer encapsulated gold nanoparticles
poly pEGylated dendrimer encapsulated gold nanoparticles
RGD peptide modified multifunctional dendrimer encapsulated gold nanoparticles
hyaluronic encapsulated gold nanoparticles
of chitosan wrapped gold nanoparticles
diatrizoic acid / folate plurality modified Functional dendrimer-encapsulated gold nanoparticles Au DENPs
targeting liposome-encapsulated aqueous nano-gold complexes
Chitosan-modified polyurethane and chitosan-encapsulated nano-gold
folic acid-modified multifunctional targeting contrast agent Magnetic iron oxide/ Gold Nanoparticles
Folic acid modified polyamide-amine dendrimer gold nanoparticles with diatrizoic
acid, citrate-encapsulated gold
nanoparticles, gold nanoparticles functionalized molybdenum disulfide nanocomposites,
lysozyme functionalized gold nanoparticles,
Rumi Gold Nanomaterials Functionalized with Novo and Derivatives Gold Nanoparticles
Functionalized with DNA,
Peryleneimide Functionalized Gold/Silver Nanoparticles,
Calixarene Functionalized Gold Nanoparticles,
Lysine Modified Peryleneimide Functionalized Gold Nanoparticles
Functionalized gold nanoparticles coated with multi-layer shells
Low algebraic PAMAM coated gold nanoparticles modified with lactobionic acid
Lipoic acid functionalized gold nanoparticles Dendritic
polyphenylene/gold composite nanoparticles
Functionalized Pd@Au nanoparticles
Antioxidant ligand functionalized gold nanocomposites
Functionalized diamond nanoparticles
Polypeptide functionalized gold nanoparticles
Nano-gold particles wrapped PEG functionalized PAMAM dendrimers
Gold nanoparticles modified thiophenol functionalized graphene composite materials
Folic acid modified multifunctional targeting contrast agent Magnetic iron oxide/gold composite nanoparticles
Terpyridine derivative ligand and β-diketone Rare earth complexes coated gold nanoparticles, gold
nanoparticles modified multi-walled carbon nanotubes (MWCNTs)
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