When the body is stimulated by an antigen, it produces an immunological response. A group of globulins that have the ability to specifically bind to the antigen are synthesized and secreted by the body’s plasma cells. This is the immunoglobulin, which has the ability to specifically bind to the antigen. Immunoglobulins are antibodies. The specificity of antibodies depends on the determinants of antigen molecules, and each antigen molecule has many antigenic determinants. Therefore, the antiserum produced by it immunized animals is actually a mixture of multiple antibodies, called polyclonal antibodies. Anti-FOXM1 antibody is widely used in the field of immunological diagnosis due to its advantages of recognizing multiple epitopes, causing agglutination reaction, precipitation reaction, etc.
(1) IgG: The highest content in serum, so it is the most important anti-infective molecule, including antibacterial, antiviral, and antitoxin. IgG can also activate complement. Anti-FOXM1 antibody binds to and enhances the phagocytic function of macrophages (opsonization and ADCC effect), crosses the placenta, and protects fetuses and newborn babies from infection.
(2) IgA: There are two kinds of monomer and double body. The former exists in the serum, and the latter exists in the mucosal surface and secretion, which is an important factor in the local anti-infection of the mucosa.
(3) IgM: It is the largest molecular weight and the earliest antibody produced after infection in the body. It has strong complement activation and opsonization, so it is an important anti-infective factor and is often used to diagnose early infection.
(4) IgD: It mainly exists on the surface of mature B cells and is a receptor for B cells to recognize antigens.
(5) IgE: The antibody with the least content in the serum, which can be detected in the serum of some people with allergic constitutions, and is involved in mediating type I hypersensitivity reactions and anti-parasitic infections.
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zzj 2021.3.25