Functional proteomics is the large-scale study of proteins at the level of functional activity (such as expression and modification). Research on complex diseases such as cancer has shown that genetic changes do not explain all the causes of the disease. Changes in protein levels and structure have also been shown to play a key role in tumor development and progression, and genetic changes do not reflect this. In cancer, the development of the disease usually requires several genetic and epigenetic changes. Today, I will introduce to you a comprehensive resource for accessing, visualizing and analyzing the functional proteomics of patient tumor samples: TCPA
This website combines Reverse Protein Array (RPPA) and TCGA's proteomic database, which can be combined with TCGA's clinical data for subsequent analysis.
Each system includes 4 aspects, and the basic operations are the same. Here we briefly introduce the use of the database using tumor samples as an example.
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Source: 51xxziyuan.com