The ChIPBase database is an online tool developed by the team of Professor Qu Liheng from the School of Life Sciences, Sun Yat-Sen University. The school badge of Sun Yat-Sen University is marked in the upper right corner of the webpage. There is also an artifact developed by Sun Yat-sen University in the database, namely Encori database (formerly Starbase database). I need to remind everyone that whether these two databases can be used depends on fate, and sometimes they will be forbidden to access. If you can't get in, maybe it will be fine after a while. The "Release notes" on the right side of the homepage shows the update log of the database. The latest update time is 2016-11-23, and the current version is 2.3.4. ChIPBase database collected chip_seq data from 10 species in 10200 data sets, sorted out the transcriptional regulatory network between transcription factors and various genes, and also included histone modification data. Let's pull down the page to see the general analysis process:
Simply put, it is to analyze the region of the transcription factor binding site from the chip_seq data of the transcription factor, which is called peak; through peak, the motif of the binding region can be further analyzed; and the transcription factor and various genes can also be obtained through gene annotation. The relationship between the regulation and control; finally, through the analysis of nearly 10,000 tumor samples and 9,100 cell lines and tissues, the co-expression relationship between transcription factors and various RNAs was obtained.
Remaining content of the article<<<<
Source: 51xxziyuan.com