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ECD is the abbreviation of Extracellular Domain, which refers to the extracellular part of a transmembrane protein (extracellular region of a membrane protein). It usually contains some functional domains, such as ligand binding domain, receptor activation domain, and dimerization arm. wait. The structure and function of the ECD are important for understanding the signaling mechanisms of transmembrane proteins. This part of the structural domain is marked on UniProt.
UniProt official website: UniProtKB
For example, phospholipid transporting ATPase ABCA1_HUMAN:
In its sequence, 43~639 is the extracellular region, as follows:
The relevant protein structure PDB is 5XJY, ie:
observe the sequence region of the PDB as follows:
select #1:43-639,1372-1656
Extracellular sequence:
The sequence is consistent with the UniProt official website, that is:
Regarding the extracellular domain (ECD) of membrane proteins, which is an important characteristic of antigens, it is necessary to focus on binding with antibodies.