Correct, if you use items with type "Zabbix agent" (so called passive checks). They will not work.
Still older agents (prior to 4.0) work well with 4.0.x server if the item type is "Zabbix agent (active)".
windows zabbix 客户端采用主动上报的方式,可以使用任意客户端版本,而无需关心zabbix server的模板