DEF the Test (): wb2 = openpyxl.Workbook () # Create an excel objects wb2.save ( " a.xlsx " ) # save excel and named a.xlsx wb2 = openpyxl.load_workbook ( ' a.xlsx ' ) # load excel data sheets2 = wb2.sheetnames # acquired excel sheet of the set of tables Sheet2 = WB2 [sheets2 [0]] # Get the first sheet excel table Print (Sheet2 [ ' A1 ' ] .Value) Sheet2 [ ' A1 ' ]. = value " My" # Set the first value sheet table is My Print (Sheet2 [ ' A1 ' ] .Value) wb2.save ( ' b.xlsx ' ) # save this excel as b.xlsx, remember to save otherwise not write go wb2.close ()