Case naming rules for gene proteins of different species of human and mouse Human gene names: all capitals + italics Naming rules for mouse protein names

While we use human
designations in this paper, we note that,
according to HGNC guidelines, most vertebrates
use all uppercase letters for genes and proteins
(italics for genes), rodents use title case for
genes (uppercase for proteins), Xenopus and
zebrafish use lower case for genes and title case

Human genes: all caps + italics

Mouse genes: capital letters + italics

HUMAN PROTEIN: ALL CAPS

Mouse protein: all caps

1 General rules

· Use commonly accepted gene/protein names and symbols in your article (see below)

· Sometimes recognized gene/protein names or symbols are no longer valid. In this case, the first reference to the gene/protein needs to be listed with the approved name followed by the bracketed description (formerly known as XXX). For example, "We used an antibody against the POU5F1 protein (formerly OCT-4)...". Be careful to use the correct symbol instead of the usual name.

2 Different species have different rules

1. Mouse/Rat/Chicken

(1) General naming rules (applicable to mice, rats and chickens):

· The full name of the gene is not italicized or Greek letters are used

For example: insulin-like growth factor 1 (insulin-like growth factor 1)

· Gene symbols do not use Greek letters and hyphens, use italics, the first letter is capitalized, and the rest are lowercase.

For example: Igf1 (italics) (insulin-like growth factor 1)

· Protein names are the same as gene symbols, but are not italicized and are in all caps

For example: IGF1

· Gene symbols and prescribed formats for mRNA and cDNA

例如： "... levels of* Igf1* (italicized) mRNA increased when..."

· The mutant allele first mentioned should be listed in detail

例如：Igf1tm1Arge/Igf1tm1Arge (italicized) is one of several knockout alleles of Igf1 (italicized)

· All letters and numbers are in italics, and the allele symbol (tm1Arge) is in superscript

· After the detailed description above, the homozygous knockout can be expressed as Igf1-/- (all letters are in italics, and - / - are in superscript); the heterozygote is *Igf1 + / - *, etc.

(2) For details of these naming regulations, see:

· (mouse, rat, chicken) http://www.informatics.jax.org/

· (specifically for rats) http://rgd.mcw.edu/

· MGI naming: http://www.informatics.jax.org/mgihome/nomen/index.shtml

· A quick guide to genetic MGI:

http://www.informatics.jax.org/mgihome/nomen/short_gene.shtml

1. Humans/non-human primates/domestic animals/default other species except mice, rats, fish, insects, flies

· Complete gene names without italics or Greek letters

For example: insulin-like growth factor 1 (insulin-like growth factor 1)

· Gene symbols do not use Greek letters and hyphens. Gene symbols are in italics and all letters are in capital letters.

For example: IGF1 (italics)

· The name of the protein is the same as the gene symbol, but without italics and in all capital letters

For example: IGF1

· Gene symbols and prescribed formats for mRNA and cDNA

例如："... levels of IGF1 (italicized) mRNA increased when..."

More websites about naming rules and symbols for genes (mutated alleles) in such species:

http://www.genenames.org/

1. Fish (applies to all fish)

· Complete gene names in italics, all lowercase letters, no Greek letters

For example: cyclops (italic)

· Gene symbols are in italics and all lowercase

For example: cyc (italic)

· Protein names are the same as gene symbols, but only the first letter is capitalized and no italics are used.

For example: Cyc

More websites about naming rules and symbols for genes (mutated alleles) in such species:

http://zfin.org/cgi-bin/webdriver?MIval=aa-ZDB_home.apg

1. Other useful websites:

· ExPASy (Special Protein Analysis System): It is a proteomics service system provided by the Swiss Institute of Bioinformatics (SIB), which can analyze protein sequence and structure as well as two-dimensional PAGE: ( http://au.expasy.org /  )

· OMIM - Mendelian Human Genetics Database:

(www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM )

· NCBI - Entrez Gene: Provides a unified environment for querying genes by sequence and/or in NCBI's Map Viewer. You can query names, symbols, accessions, publications, GO terms, chromosome numbers, EC numbers, and many other related genes and their encoded products. ( www.ncbi.nlm.nih.gov/gene )

Author: The sister who loves sea peppers
Link: https://www.jianshu.com/p/b13f26df9b8e
Source: Jianshu
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