Life Science Group
Research old gene and young gene
CAI selection signal; CGmutation signal
Plot Neutrality : CG3 and GC1 , GC2 relationship: Flat: mutation ; positive correlation: Selection Signal
The film
Ka / Ks representing the selected pressure, Core Gene Ka / Ks is relatively small, i.e. purifying selection (negative selection).
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The second law of thermodynamics
Using the binary representation of the password table, Core Gene randomness stronger (heat two is the stronger the greater the energy entropy)
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Gene gain&loss&duplication time
Identification of Essential Gene , by way of knockout
positive selection：Old >young
In Young gene: single >duplication
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Gene age 与 signatures
Use the PCA , we found that GC can best explain the variation.
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Three Ways synonymous substitutions
Find alternative methods: 1. approximation 2. maximum likelihood method,
Definition of synonymous sites: Fig.
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Model selection consideration parameters:
AIC
BIC
LRT : Likelihood Ratio Test
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Software kaks_Calculator
Dating the divergence time