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Several factors affect the performance of
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Hardware resources (CPU, memory, disk, etc.)
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The difference between the operating system
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MySQL storage engine of choice
MyISAM: the transaction, table-level locking does not support
transaction-level storage engine, the perfect support for row-level locking, transaction ACID properties: InnoDB.But not that worse than InnoDB than MyISAM, see usage scenarios
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Database parameters
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Database design and SQL statements , there is no doubt this is the most important factor