Transfer: http://blog.sina.com.cn/s/blog_83f77c940102y76d.html
Due to the COSMIC database, the final version of annovar more to stop v77 version, as of this time is already V88 version.
annovar official gives update method, before COSMIC only variation comment file coding region, and now has added a non-coding region, and therefore need to need four files in the process of building the comment file, developers can be downloaded from the COSMIC database itself. Note, COSMIC database can also be registered when commercial mailbox, but you default designated as a school or research institutions may also lie in the past at a specified time.
Need to download the four files are:
CosmicCodingMuts.vcf
CosmicMutantExport.tsv
CosmicNCV.tsv
CosmicNonCodingVariants.vcf
构建命令：
prepare_annovar_user.pl -dbtype cosmic CosmicMutantExport.tsv -vcf CosmicCodingMuts.vcf > hg38_cosmic76.txt
prepare_annovar_user.pl -dbtype cosmic CosmicMutantExport.tsv -vcf CosmicNonCodingVariants.vcf >> hg38_cosmic76.txt
We recommend building index, because COSMIC file is growing. But the official did not provide index file, you can leave a message directly to the author wants it in annovar official website. Author reply quickly, about three days.