Under normal circumstances, NULL values are not into B-TREE index, so according to the time of taking the IS NULL queries are usually full table scan, if the record is less good, more records, the query can be very time consuming
Can be solved by creating an index
CREATE INDEX TABLE_OWNER.IX_TABLE_NAME_COL ON TABLE_OWNER.TABLE_NAME(COL,0) TABLESPACE TBS;
COL is a column containing a NULL value
Forced to take the index by adding HINT
SELECT /*+INDEX(A IX_TABLE_NAME_COL)*/* FROM TABLE_OWNER.TABLE_NAME A WHERE COL IS NULL;