Known almost from: https: //zhuanlan.zhihu.com/p/51355201
July 6, 2018, one of the pioneers in the field of epigenetic Danny Reinberg in Science published opinions (Perspectives) article [4], on " What histone modifications can be inherited and its mechanisms " were discussed. The following text is the core idea of the sort.
Chromatin two states
unmodified histone positively charged, and negatively charged DNA, both electrostatically bonded together to form nucleosomes; also having electrostatic interaction between the protein and the groups adjacent nucleosomes, thus By default, it should be dense chromatin compressed (heterochromatin, heterochromatin), in the inhibition of the gene as a whole. And whether DNA replication, transcription or repair, you need to chromatin in an open state (euchromatin, euchromatin), then the question is, how open chromatin is it?