Recombinant human CD3E丨CD28 protein solution Let’s
talk about the role of CD molecules in the immune response mechanism.
1. The functions of CD molecules are mainly divided into the following aspects
1. Participate in the mutual recognition of immune cells in the process of immune response;
2. Immune cells recognize antigens, activate, proliferate and differentiate; exert immune effect functions;
3. Participate in the differentiation of hematopoietic cells and the regulation of hematopoietic process;
4. Participate in inflammation Occurrence;
5. Participate in cell migration, such as tumor cell metastasis.
2. Clinical applications of CD molecules (CD monoclonal antibodies can be used)
1. To clarify the pathogenesis of certain diseases;
2. Widely used in immunodiagnosis of various diseases;
3. Treat transplant rejection and tumors and other diseases.
3. The commonly used CD molecules mainly include
1. CD molecules involved in T cell recognition and activation;
2. CD molecules involved in B cell recognition and activation;
3. Immunoglobulin Fc receptors.
4. CD molecules involved in T cell recognition and activation
1. [CD3E] Recombinant human T cell surface molecule CD3E, Fc tag (no animal origin), #PRP2029
CD3E is a single-pass type I membrane glycoprotein on the surface of T cells. As part of the TCR-CD3 complex on the surface of T lymphocytes, CD3E plays an important role in the adaptive immune response. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain, together with CD3-γ, CD3-δ and CD3-ζ and T cell receptor α/β and γ/δ heterodimers Forms T cell receptor-CD3 complex. The T cell receptor-CD3 complex plays an important role in coupling antigen recognition with a variety of intracellular signal transduction pathways, and is essential for the development and function of T cells. In addition, CD3E also plays an important role in the development of T cells, and CD3E gene defects can lead to severe immune deficiency. The CD3E gene is also related to women's susceptibility to type I diabetes.
2. [CD28] Recombinant human T cell surface molecule CD28, Fc tag (no animal origin), #PRP2031
CD28 molecule is a member of the Ig superfamily, expressed on CD4+ T cells in the form of a homodimer composed of two peptide chains And more than half the surface of CD8+ T cells. The CD28 molecule is an adhesion molecule on the surface of T cells and the most important co-stimulatory molecule. It can play a role in the B7-CD28 complex formed by non-covalent bonding with the ligand (B7) on the antigen presenting cell (APC) Co-stimulation. The CD28 molecule plays a key role in many T cell processes, including cytoskeleton remodeling, cytokine production, survival and differentiation. Blocking the CD28/B7 interaction may help prevent harmful activation in allergic reactions and autoimmune diseases, and enhancing this interaction can promote tumor rejection. Therefore, CD28 and its signaling pathway may prove to be a useful target for the development of new treatments.
Recombinant human CD3E/CD28 protein link:
http://www.abbkine.cn/cd3e-protein