y1 = np.array([[1, 2], [1, 3], [1, 2], [2, 2]])
y2 = np.array([[100, 200], [100,300], [100, 200], [200, 200]])
z = np.array([1, 2])
(y1 == z).all(1).any()
# True
(y2 == z).all(1).any()
# False
Reference: About python: Check whether the NumPy array contains another array