Model Generation can generate a specific two-point model (heritability 0.2, MAF 0.2)
. The parameters that can be set are: number of attributes, heritability, MAF, population prevalence, the name of SNP, the model difficulty metric used to identify quantiles, the quantile count, quantile population size
The number of
SNP sites in the Number of attributes model.
Heritability
heritability. Observable differences between individuals are caused by genetic differences. If the value of heritability is too high, then GAMETES will not be able to generate a random model
Population prevalence (K)
population The proportion of diseases in the middle, between 0 and 1, it is recommended to set the K value as the default
MAF
minimum allele frequency, 0.05 to 0.5
Quantiles
select EDM or Odds Ratio
Quantile Count to
save the number of model structures in the model output file
Quantile Population Size
According to the given model constraints, the number of random model architectures you want GAMETES to create
Quantile Count <= Quantile Population Size
Create Models
Quantile Count = 1
allows to modify three parameters: the number of attributes, penetrance (the penetrance, refers to the probability of an individual with a specific genotype combination of diseases), MAF
Marginal penetrances
only consider a single SNP locus, each Probability of genotype
https://blog.csdn.net/weixin_40427928/article/details/78326806
https://blog.csdn.net/S_gy_Zetrov/article/details/79774928