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Latest: Yan Ning Papers , Editor: Qubits
Yan Ning , a structural biologist , suddenly published a new paper in the Nature sub-journal.
And Yan Ning himself was a little surprised after learning about this:
Immediately changed the citation from in press to page number.
Then Yan Ning gave the following two comments on this article:
Any structure in the article is powerless for AI .
Actually I didn't want to post it ...
Netizens are also envious while congratulating:
So what is this structure that AI can't do anything about?
Revealing How CBD Affects Nav v 1.7 Channel
First, we need to understand two key concepts.
Cannabidiol (CBD), a phytocannabinoid widely used to treat epilepsy and pain.
Nav v 1.7 is an ion channel protein expressed in neurons, which can regulate the release of neurotransmitters in neurons.
At the same time, it is also an important target in drug research, with analgesic, anesthetic, anticancer and neuroprotective effects.
This follows a number of large clinical trials showing the efficacy of CBD in the treatment of several types of childhood epilepsy, and CBD has also been shown to relieve pain.
However, the effect of CBD on the Nav v 1.7 channel has not been fully studied.
This study by Yan Ning's team solved the problem of how CBD interacts with Nav v 1.7 channel and affects its function.
This article uses cryo-electron microscopy (cryo-EM) technology to study the complex structure of human Nav1.7 channel and CBD.
First, the researchers expressed human Nav v 1.7 channels through a stable cell line, and treated the cells with a low concentration of CBD to obtain a complex of Nav v 1.7 channels and CBD.
The complex was then imaged using cryo-electron microscopy and the structure resolved.
With this approach, the researchers were able to observe the detailed structure of the Nav v 1.7 channel-CBD complex, including the α1, β1, and β2 subunits of the Nav 1.7 channel, as well as the binding site of the CBD molecule.
From the results, the study found that CBD can significantly reduce the activity of Nav v 1.7 channel; and found that CBD is mainly bound to the F-binding site of Nav v 1.7 channel.
This provides a basis for further research on the interaction between Nav1.7 channels and CBD, and also provides a theoretical basis for the development of new therapeutic methods.
research team
The corresponding author of this paper is Yan Ning, a structural biologist. He is mainly engaged in the research of important membrane transport proteins related to diseases, the structure and working mechanism of voltage-gated ion channels, and the molecular mechanism of membrane proteins regulating cholesterol metabolism pathways.
Yan Ning obtained a bachelor's degree from the Department of Biological Science and Technology of Tsinghua University; a doctorate degree from the Department of Molecular Biology of Princeton University, under the tutelage of Professor Shi Yigong; and then also engaged in postdoctoral research work here.
She was employed by the School of Medicine of Tsinghua University after her postdoctoral fellowship; Yan Ning became the dean of the Shenzhen Academy of Medical Sciences at the end of last year and the director of the Shenzhen Bay Laboratory in March this year.
Reference link:
[1]https://weibo.com/1656918431/N5M6GfhBg
[2]https://www.nature.com/articles/s41467-023-39307-6
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