After the macOS computer is upgraded to the latest Big Sur system, some software or registration will appear "You do not have permission to open the application" situation, such as the activation tool of autocad, xf-adsk20.app or OmniFocus registration machine, A pop-up prompt: You do not have permission to open the application "OmniFocus Registration Machine", as shown in the figure below, then how to solve this problem?
Don't worry when you encounter this situation, it is very simple, installing upx can solve the problem of Big Sur system prompting no permission.
Let's solve this problem with the editor of macz. The specific steps are as follows:
1. Download the upx permission repair tool:
link: https://pan.baidu.com/s/1Xt5iIUcl_yzsEpJUTjz5Wg Password: tpnn
Drag into the upx on the left and drag to the application folder on the right
2. Drag the software that cannot be opened to the application directory, such as the OmniFocus registration machine, right-click the software icon, select "Show Package Contents", and enter the Contents-MacOS directory;
3. Open the terminal and copy the command: sudo /Applications/upx -d (note that there is a space at the end) and paste it into the terminal
4. Drag the icon in the MacOS directory to the terminal 
6. Get a similar command: sudo /Applications/upx -d /Users/macdown/Desktop/OmniFocus\ \ Register machine.app/Contents/MacOS/CORE\ Keygen 
6. Press back Car key, prompt to enter the password, here the password is not displayed, just press the Enter key after entering the password. 
7. Return to the prompt "Unpacked 1 file." to indicate the operation is successful.
8. At this time, the software should be able to open normally:
The above is the solution brought to you by the editor of Big Sur that you do not have permission to open the application. I hope it can help you. For more Mac tutorials, please follow macz.